Abstract
Electrophysiological studies have been performed on 62 subjects with malignant lymphoma and the results compared with those of 35 control subjects matched for age. There was evidence of impairment of conduction consistent with a generalized peripheral neuropathy in 22 subjects (35%). Histological and electronmicroscopic studies were performed on sural nerve biopsy material from five subjects, and the pathological abnormalities of the myelinated fibres were those of axonal degeneration and segmental demyelination. The unmyelinated fibres were not affected.
Full text
PDF








Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ALLISON R. S., GORDON D. S. Reticulosis of the nervous system simulating acute infective polyneuritis. Lancet. 1955 Jul 16;269(6881):120–122. doi: 10.1016/s0140-6736(55)92119-x. [DOI] [PubMed] [Google Scholar]
- Arnold N., Harriman D. G. The incidence of abnormality in control human peripheral nerves studied by single axon dissection. J Neurol Neurosurg Psychiatry. 1970 Feb;33(1):55–61. doi: 10.1136/jnnp.33.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BARRON K. D., ROWLAND L. P., ZIMMERMAN H. M. Neuropathy with malignant tumor metastases. J Nerv Ment Dis. 1960 Jul;131:10–31. doi: 10.1097/00005053-196007000-00002. [DOI] [PubMed] [Google Scholar]
- BLANCHARD B. M. Peripheral neuropathy (non-invasive) associated with lymphoma. Ann Intern Med. 1962 May;56:774–778. doi: 10.7326/0003-4819-56-5-774. [DOI] [PubMed] [Google Scholar]
- DAWSON G. D. The relative excitability and conduction velocity of sensory and motor nerve fibres in man. J Physiol. 1956 Feb 28;131(2):436–451. doi: 10.1113/jphysiol.1956.sp005473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dyck P. J., Gutrecht J. A., Bastron J. A., Karnes W. E., Dale A. J. Histologic and teased-fiber measurements of sural nerve in disorders of lower motor and primary sensory neurons. Mayo Clin Proc. 1968 Feb;43(2):81–123. [PubMed] [Google Scholar]
- Fullerton P. M., O'Sullivan D. J. Thalidomide neuropathy: a clinical electrophysiological, and histological follow-up study. J Neurol Neurosurg Psychiatry. 1968 Dec;31(6):543–551. doi: 10.1136/jnnp.31.6.543. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GILLIATT R. W., SEARS T. A. Sensory nerve action potentials in patients with peripheral nerve lesions. J Neurol Neurosurg Psychiatry. 1958 May;21(2):109–118. doi: 10.1136/jnnp.21.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gutmann E., Sanders F. K. Recovery of fibre numbers and diameters in the regeneration of peripheral nerves. J Physiol. 1943 Mar 25;101(4):489–518. doi: 10.1113/jphysiol.1943.sp004002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUTCHINSON E. C., LEONARD B. J., MAUDSLEY C., YATES P. O. Neurological complications of the reticuloses. Brain. 1958 Mar;81(1):75–92. doi: 10.1093/brain/81.1.75. [DOI] [PubMed] [Google Scholar]
- Hildebrand J., Coërs C. The neuromuscular function in patients with malignant tumours. Electromyographic and histological study. Brain. 1967 Mar;90(1):67–82. doi: 10.1093/brain/90.1.67. [DOI] [PubMed] [Google Scholar]
- Lascelles R. G., Thomas P. K. Changes due to age in internodal length in the sural nerve in man. J Neurol Neurosurg Psychiatry. 1966 Feb;29(1):40–44. doi: 10.1136/jnnp.29.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moody J. F. Electrophysiological investigations into the neurological complications of carcinoma. Brain. 1965 Dec;88(5):1023–1036. doi: 10.1093/brain/88.5.1023. [DOI] [PubMed] [Google Scholar]
- O'Sullivan D. J., Swallow M. The fibre size and content of the radial and sural nerves. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):464–470. doi: 10.1136/jnnp.31.5.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ochoa J., Mair W. G. The normal sural nerve in man. I. Ultrastructure and numbers of fibres and cells. Acta Neuropathol. 1969;13(3):197–216. doi: 10.1007/BF00690642. [DOI] [PubMed] [Google Scholar]
- Ochoa J., Mair W. G. The normal sural nerve in man. II. Changes in the axons and Schwann cells due to ageing. Acta Neuropathol. 1969;13(3):217–239. doi: 10.1007/BF00690643. [DOI] [PubMed] [Google Scholar]
- Swallow M. Fibre size and content of the anterior tibial nerve of the foot. J Neurol Neurosurg Psychiatry. 1966 Jun;29(3):205–213. doi: 10.1136/jnnp.29.3.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THOMAS P. K. Growth changes in the myelin sheath of peripheral nerve fibres in fishes. Proc R Soc Lond B Biol Sci. 1955 Mar 15;143(912):380–391. doi: 10.1098/rspb.1955.0018. [DOI] [PubMed] [Google Scholar]
- Trojaborg W., Frantzen E., Andersen I. Peripheral neuropathy and myopathy associated with carcinoma of the lung. Brain. 1969 Mar;92(1):71–82. doi: 10.1093/brain/92.1.71. [DOI] [PubMed] [Google Scholar]
- Vizoso A. D., Young J. Z. Internode length and fibre diameter in developing and regenerating nerves. J Anat. 1948 Apr;82(Pt 1-2):110–134.1. [PMC free article] [PubMed] [Google Scholar]
- Walsh J. C., McLeod J. G. Alcoholic neuropathy. An electrophysiological and histological study. J Neurol Sci. 1970 May;10(5):457–469. doi: 10.1016/0022-510x(70)90025-0. [DOI] [PubMed] [Google Scholar]


