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. 1971 Apr;34(2):195–199. doi: 10.1136/jnnp.34.2.195

Relation of hypermagnesaemia to activity and neuroleptic drug therapy in schizophrenic states

C J Brackenridge 1, Ivor H Jones 1
PMCID: PMC493734  PMID: 5571604

Abstract

In a study designed to explain conflicting reports of hypermagnesaemia in schizophrenia, significantly higher concentrations of plasma-magnesium were found in phenothiazine-treated schizophrenic women than in normal women of the same age. This did not apply to men. Magnesium levels were inversely related to motor activity in untreated chronic schizophrenic men in hospital as well as in patients of both sexes receiving butyrophenone or phenothiazine derivatives. The magnesium concentration fell significantly when institutionalized schizophrenic and non-schizophrenic men were placed on neuroleptic medication. It is concluded that age, sex, pharmacotherapy, and level of activity all influence the metabolism of magnesium in schizophrenic subjects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brackenridge C. J., Jones I. H. The effect of neuroleptic drug treatment on plasma fibrinogen concentrations in schizophrenic states. J Neurol Neurosurg Psychiatry. 1968 Aug;31(4):326–329. doi: 10.1136/jnnp.31.4.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brackenridge C. J., McDonald C. The concentrations of magnesium and potassium in erythrocytes and plasma of geriatric patients with psychiatric disorders. Med J Aust. 1969 Aug 23;2(8):390–394. doi: 10.5694/j.1326-5377.1969.tb107155.x. [DOI] [PubMed] [Google Scholar]
  3. CADE J. F. A SIGNIFICANT ELEVATION OF PLASMA MAGNESIUM LEVELS IN SCHIZOPHRENIA AND DEPRESSIVE STATES. Med J Aust. 1964 Feb 8;1:195–196. doi: 10.5694/j.1326-5377.1964.tb114274.x. [DOI] [PubMed] [Google Scholar]
  4. CARR M. H., FRANK H. A. Normal serum electrolytes with a note on seasonal and menstrual variation. J Lab Clin Med. 1957 Feb;49(2):246–252. [PubMed] [Google Scholar]
  5. GOTTFRIED S. P., WILLNER H. H. Blood chemistry of schizophrenic patients before, during and after insulin shock therapy; preliminary studies. Arch Neurol Psychiatry. 1949 Dec;62(6):809–817. doi: 10.1001/archneurpsyc.1949.02310180110014. [DOI] [PubMed] [Google Scholar]
  6. HEATON F. W., PARSONS F. M. The metabolic effect of high magnesium intake. Clin Sci. 1961 Dec;21:273–284. [PubMed] [Google Scholar]
  7. Harris A. D., Letemendia F. J., Willems P. J. A rating scale of the mental state: for use in the chronic population of the psychiatric hospital. Br J Psychiatry. 1967 Sep;113(502):941–949. doi: 10.1192/bjp.113.502.941. [DOI] [PubMed] [Google Scholar]
  8. Jones I. H., Davies J., Buckle R., Hanna W. H., Pikler N. Comparison of methylperidol and trifluoperazine in the treatment of chronic, underactive schizophrenic patients. Aust N Z J Psychiatry. 1970 Sep;4(3):143–147. doi: 10.3109/00048677009159325. [DOI] [PubMed] [Google Scholar]
  9. Keating F. R., Jr, Jones J. D., Elveback L. R., Randall R. V. The relation of age and sex to distribution of values in healthy adults of serum calcium, inorganic phosphorus, magnesium, alkaline phosphatase, total proteins, albumin, and blood urea. J Lab Clin Med. 1969 May;73(5):825–834. [PubMed] [Google Scholar]
  10. METZ B., MOURS-LAROCHE M. F. Evolution de la concentration plasmatique et de l'excrétion urinaire du magnésium au cours du nycthémère chez l'homme normal. C R Seances Soc Biol Fil. 1955 Mar;149(5-6):579–582. [PubMed] [Google Scholar]
  11. Masiak M., Bernaśkiewicz E. Badania poziomu magnezu w surowicy i w krwinkach czerwonych we wczesnej schizofrenii. Przegl Lek. 1965;21(9):547–548. [PubMed] [Google Scholar]
  12. Roberts L. B. The normal ranges, with statistical analysis for seventeen blood constituents. Clin Chim Acta. 1967 Apr;16(1):69–78. doi: 10.1016/0009-8981(67)90271-9. [DOI] [PubMed] [Google Scholar]
  13. Seal U. S., Eist H. Serum magnesium concentration in schizophrenia and epilepsy. Clin Chem. 1967 Nov;13(11):1021–1023. [PubMed] [Google Scholar]
  14. VENABLES P. H. A short scale for rating activity-withdrawal in schizophrenics. J Ment Sci. 1957 Jan;103(430):197–199. doi: 10.1192/bjp.103.430.197. [DOI] [PubMed] [Google Scholar]
  15. WALLACH S., CAHILL L. N., ROGAN F. H., JONES H. L. Plasma and erythrocyte magnesium in health and disease. J Lab Clin Med. 1962 Feb;59:195–210. [PubMed] [Google Scholar]
  16. Walser M. Magnesium metabolism. Ergeb Physiol. 1967;59:185–296. doi: 10.1007/BF02269144. [DOI] [PubMed] [Google Scholar]
  17. Whang R., Wagner R. The influence of venous occlusion and exercise on serum magnesium concentration. Metabolism. 1966 Jul;15(7):608–612. doi: 10.1016/0026-0495(66)90122-3. [DOI] [PubMed] [Google Scholar]
  18. Whittingham S., Mackay I. R., Jones I. H., Davies B. Absence of brain antibodies in patients with schizophrenia. Br Med J. 1968 Feb 10;1(5588):347–348. doi: 10.1136/bmj.1.5588.347. [DOI] [PMC free article] [PubMed] [Google Scholar]

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