Abstract
Cortisol concentration was estimated by a competitive protein-binding method in the lumbar cerebrospinal fluid (CSF) of patients suffering from depression or from mania, and compared with the CSF cortisol concentration of neurological control patients not suffering from an affective disorder. There were no significant differences between the groups.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BECK A. T., WARD C. H., MENDELSON M., MOCK J., ERBAUGH J. An inventory for measuring depression. Arch Gen Psychiatry. 1961 Jun;4:561–571. doi: 10.1001/archpsyc.1961.01710120031004. [DOI] [PubMed] [Google Scholar]
- BLISS E. L., SANDBERG A. A., NELSON D. H., EIK-NES K. The normal levels of 17-hydroxycorticosteroids in the peripheral blood of man. J Clin Invest. 1953 Sep;32(9):818–823. doi: 10.1172/JCI102798. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brooksbank B. W., Coppen A. Plasma II-hydroxycorticosteroids in affective disorders. Br J Psychiatry. 1967 Apr;113(497):395–404. doi: 10.1192/bjp.113.497.395. [DOI] [PubMed] [Google Scholar]
- Coppen A. J. Depressed states and indolealkylamines. Adv Pharmacol. 1968;6(Pt B):283–291. doi: 10.1016/s1054-3589(08)60328-2. [DOI] [PubMed] [Google Scholar]
- Coppen A. J. The chemical pathology of the affective disorders. Sci Basis Med Annu Rev. 1970:179–210. [PubMed] [Google Scholar]
- Curzon G. Tryptophan pyrrolase--a biochemical factor in depressive illness? Br J Psychiatry. 1969 Dec;115(529):1367–1374. doi: 10.1192/bjp.115.529.1367. [DOI] [PubMed] [Google Scholar]
- Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967 Dec;6(4):278–296. doi: 10.1111/j.2044-8260.1967.tb00530.x. [DOI] [PubMed] [Google Scholar]
- Kawai A., Yates F. E. Interference with feedback inhibition of adrenocorticotropin release by protein binding of corticosterone. Endocrinology. 1966 Dec;79(6):1040–1046. doi: 10.1210/endo-79-6-1040. [DOI] [PubMed] [Google Scholar]
- Keller N., Richardson U. I., Yates F. E. Protein binding and the biological activity of corticosteroids: in vivo induction of hepatic and pancreatic alanine aminotransferases by corticosteroids in normal and estrogen-treated rats. Endocrinology. 1969 Jan;84(1):49–62. doi: 10.1210/endo-84-1-49. [DOI] [PubMed] [Google Scholar]
- Lapin I. P., Oxenkrug G. F. Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect. Lancet. 1969 Jan 18;1(7586):132–136. doi: 10.1016/s0140-6736(69)91140-4. [DOI] [PubMed] [Google Scholar]
- Murphy B. E. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab. 1967 Jul;27(7):973–990. doi: 10.1210/jcem-27-7-973. [DOI] [PubMed] [Google Scholar]
- ROMANOFF L. P., MORRIS C. W., WELCH P., RODRIGUEZ R. M., PINCUS G. The metabolism of cortisol-4-C14 in young and elderly men. I. Secretion rate of cortisol and daily excretion of tetrahydrocortisol, allotetrahydrocortisol, tetrahydrocortisone and cortolone (20alpha and 20beta). J Clin Endocrinol Metab. 1961 Nov;21:1413–1425. doi: 10.1210/jcem-21-11-1413. [DOI] [PubMed] [Google Scholar]
- Uete T., Nishimura S., Oya H., Shimomura T., Tatebayashi Y. Corticosteroid levels in blood and cerebrospinal fluid in various diseases. J Clin Endocrinol Metab. 1970 Feb;30(2):208–214. doi: 10.1210/jcem-30-2-208. [DOI] [PubMed] [Google Scholar]
- YATES F. E., URQUHART J. Control of plasma concentrations of adrenocortical hormones. Physiol Rev. 1962 Jul;42:359–433. doi: 10.1152/physrev.1962.42.3.359. [DOI] [PubMed] [Google Scholar]
