Figure 5.

Combinational therapy preserves the GVL response. BDF1 recipient mice were lethally irradiated (1200cGY) and transplanted with 5 × 10⁶ TCD-BM, 2 × 10⁶ CD4⁺ iTregs, 4 × 10⁶ CD8⁺ iTregs, and 5 × 10³ luc-P815 cells. Three days later, 2 × 10⁶ B6 CD25-depleted Teffs were injected.  Recipients were monitored for survival (A), tumor mortality (B), and tumor load (C) for 80 d, n = 15.  *p < .05; **p < .01; ***p < .001.