Abstract
A technique is described for the electrophysiological investigation of motor-point muscle biopsies and the data from 13 biopsies are reported. It was not possible to demonstrate any influence of disease upon the resting potentials of individual biopsies, but resting potentials were in general lower than those reported for limb muscle in vivo. Miniature end-plate potentials (MEPPs) in clinically normal limb muscle were smaller and more frequent than those previously described in isolated intercostal muscle. In two biopsies from myasthenic patients very small amplitude MEPPs were recorded and, in one of these, MEPPs were also of very low frequency, possibly associated with the severity of the disease. The frequency and amplitude of MEPPs in muscular dystrophy and neurogenic disease have been reported and the possible significance of these findings is discussed.
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- Albuquerque E. X., McIsaac R. J. Fast and slow mammalian muscles after denervation. Exp Neurol. 1970 Jan;26(1):183–202. doi: 10.1016/0014-4886(70)90099-3. [DOI] [PubMed] [Google Scholar]
- Allen D. E., Johnson A. G., Woolf A. L. The intramuscular nerve endings in dystrophia myotonica--a biopsy study by vital staining and electron microscopy. J Anat. 1969 Jul;105(Pt 1):1–26. [PMC free article] [PubMed] [Google Scholar]
- BOYD I. A., MARTIN A. R. Spontaneous subthreshold activity at mammalian neural muscular junctions. J Physiol. 1956 Apr 27;132(1):61–73. doi: 10.1113/jphysiol.1956.sp005502. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CREUTZFELDT O. D., ABBOTT B. C., FOWLER W. M., PEARSON C. M. MUSCLE MEMBRANE POTENTIALS IN EPISODIC ADYNAMIA. Electroencephalogr Clin Neurophysiol. 1963 Jun;15:508–519. doi: 10.1016/0013-4694(63)90071-3. [DOI] [PubMed] [Google Scholar]
- ELMQVIST D., HOFMANN W. W., KUGELBERG J., QUASTEL D. M. AN ELECTROPHYSIOLOGICAL INVESTIGATION OF NEUROMUSCULAR TRANSMISSION IN MYASTHENIA GRAVIS. J Physiol. 1964 Nov;174:417–434. doi: 10.1113/jphysiol.1964.sp007495. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goodgold J., Eberstein A. Transmembrane potentials of human muscle cells in vivo. Exp Neurol. 1966 Jul;15(3):338–346. doi: 10.1016/0014-4886(66)90056-2. [DOI] [PubMed] [Google Scholar]
- Hofmann W. W., Alston W., Rowe G. A study of individual neuro-muscular junctions in myotonia. Electroencephalogr Clin Neurophysiol. 1966 Dec;21(6):521–537. doi: 10.1016/0013-4694(66)90171-4. [DOI] [PubMed] [Google Scholar]
- KATZ B., THESLEFF S. On the factors which determine the amplitude of the miniature end-plate potential. J Physiol. 1957 Jul 11;137(2):267–278. doi: 10.1113/jphysiol.1957.sp005811. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McComas A. J., Mrozek K., Bradley W. G. The nature of the electrophysiological disorder in adynamia episodica. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):448–452. doi: 10.1136/jnnp.31.5.448. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McComas A. J., Mrozek K. The electrical properties of muscle fiber membranes in dystrophia myotonica and myotonia congenita. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):441–447. doi: 10.1136/jnnp.31.5.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morris C. J. Human skeletal muscle fibre type grouping and collateral re-innervation. J Neurol Neurosurg Psychiatry. 1969 Oct;32(5):440–444. doi: 10.1136/jnnp.32.5.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morris C. J. The significance of intermediate fibres in reinnervated human skeletal muscle. J Neurol Sci. 1970 Aug;11(2):129–136. doi: 10.1016/0022-510x(70)90123-1. [DOI] [PubMed] [Google Scholar]
- Woolf A. L. Morphology of the myasthenic neuromuscular junction. Ann N Y Acad Sci. 1966 Jan 26;135(1):35–59. doi: 10.1111/j.1749-6632.1966.tb45461.x. [DOI] [PubMed] [Google Scholar]