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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Neuron. 2016 Jun 16;91(1):146–154. doi: 10.1016/j.neuron.2016.05.023

Figure 5. TMC-1 is not involved in mediating acidic pH-activated currents in ASH neurons.

Figure 5

(A) Acidic pH induces avoidance behavior that depends on OSM-9 but not TMC-1. osm-9(ky10) but not tmc-1(ok1859) or tmc-2(ok1302) mutant worms showed a defect in this behavior. The basal response rate resulted from spontaneous reversals. n=20. Error bars: SEM. **p<0.005, ***p<0.0005 (ANOVA with Dunnett’s test).

(B) Acidic pH evokes an inward current in ASH neurons and this current is reduced in osm-9 mutant but remained normal in tmc mutants. Bath solution (pH 3) was perfused towards the nose tip where ASH sensory endings are localized. Shown are sample traces. Voltage: −60 mV.

(C) Bar graph summarizing the data in (B). n≥8. Error bars: SEM. **p<0.005 (ANOVA with Dunnett’s test).