Abstract
The measurement of terminal deoxynucleotidyl transferase (TDT) activity in leukaemic blasts of 26 cases of acute lymphoblastic leukaemia (ALL) (13 children less than 14 years, 13 adults greater than 14 years) demonstrated significantly greater activities of the enzyme on a proportion of the adults. The predominant cytological sub-type in the adult patients was L2 (FAB classification) whereas L1 cytological sub-type dominated in the childhood group. There was no relation between TDT values and FAB sub-type but the highest activities in the childhood group were seen in patients assessed at the time of relapse. We conclude that continued use of quantitative TDT estimations may provide useful information in further characterising the currently recognised cytological and immunological sub-types in ALL.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A., Gralnick H. R., Sultan C. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 1976 Aug;33(4):451–458. doi: 10.1111/j.1365-2141.1976.tb03563.x. [DOI] [PubMed] [Google Scholar]
- Bollum F. J. Terminal deoxynucleotidyl transferase as a hematopoietic cell marker. Blood. 1979 Dec;54(6):1203–1215. [PubMed] [Google Scholar]
- Catovsky D., Pittman S., O'Brien M., Cherchi M., Costello C., Foa R., Pearce E., Hoffbrand A. V., Janossy G., Ganeshaguru K. Multiparameter studies in lymphoid leukemias. Am J Clin Pathol. 1979 Oct;72(4 Suppl):736–745. [PubMed] [Google Scholar]
- Donlon J. A., Jaffe E. S., Braylan R. C. Terminal deoxynucleotidyl transferase activity in malignant lymphomas. N Engl J Med. 1977 Sep 1;297(9):461–464. doi: 10.1056/NEJM197709012970901. [DOI] [PubMed] [Google Scholar]
- Habeshaw J. A., Catley P. F., Stansfield A. G., Ganeshaguru K., Hoffbrand A. V. Terminal deoxynucleotidyl transferase activity in lymphoma. Br J Cancer. 1979 May;39(5):566–569. doi: 10.1038/bjc.1979.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoffbrand A. V., Ganeshaguru K., Janossy G., Greaves M. F., Catovsky D., Woodruff R. K. Terminal deoxynucleotidyl-transferase levels and membrane phenotypes in diagnosis of acute leukaemia. Lancet. 1977 Sep 10;2(8037):520–523. doi: 10.1016/s0140-6736(77)90662-6. [DOI] [PubMed] [Google Scholar]
- Janossy G., Hoffbrand A. V., Greaves M. F., Ganeshaguru K., Pain C., Bradstock K. F., Prentice H. G., Kay H. E., Lister T. A. Terminal transferase enzyme assay and immunological membrane markers in the diagnosis of leukaemia: a multiparameter analysis of 300 cases. Br J Haematol. 1980 Feb;44(2):221–234. doi: 10.1111/j.1365-2141.1980.tb01204.x. [DOI] [PubMed] [Google Scholar]
- Long J. C., McCaffrey R. P., Aisenberg A. C., Marks S. M., Kung P. C. Terminal deoxynucleotidyl transferase positive lymphoblastic lymphoma: a study of 15 cases. Cancer. 1979 Dec;44(6):2127–2139. doi: 10.1002/1097-0142(197912)44:6<2127::aid-cncr2820440625>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
- Pangalis G. A., Beutler E. Terminal transferase in leukemia of adults. Acta Haematol. 1979;62(4):199–205. doi: 10.1159/000207572. [DOI] [PubMed] [Google Scholar]