Abstract
Cardiovascular disturbances were found to be a common feature of patients with the Guillian-Barré syndrome who were severely paralysed, requiring assisted ventilation. Glycosuria was noted in association with these disturbances, and in five patients investigated we found impaired glucose tolerance tests at the height of the paralysis. Catecholamine and 17-hydroxycorticosteroid urinary excretions were found to be high in four patients investigated when the neuropathy was most severe, and in one patient plasma cortisol levels were high with loss of diurnal variation. With recovery from paralysis cardiovascular disturbances became less marked, catecholamine and 17-hydroxycorticosteroid urinary excretions reverted to normal, glucose tolerance improved but remained abnormal in three patients during the period of observation. It is suggested that increased levels of catecholamines and cortisol contributed to the development of impaired glucose tolerance and cardiovascular disturbances.
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Selected References
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- APPENZELLER O., MARSHALL J. VASOMOTOR DISTURBANCE IN LANDRY-GUILLIAN-BARR'E SYNDROME. Arch Neurol. 1963 Oct;9:368–372. doi: 10.1001/archneur.1963.00460100056006. [DOI] [PubMed] [Google Scholar]
- Clark A., Timms B. G. Reduced 2,6-dichlorophenol-indophenol as a replacement for o-tolidine in the enzymatic determination of blood glucose. Clin Chim Acta. 1968 May;20(2):352–354. doi: 10.1016/0009-8981(68)90171-x. [DOI] [PubMed] [Google Scholar]
- EIBEN R. M., GERSONY W. M. RECOGNITION, PROGNOSIS AND TREATMENT OF THE GUILLAIN-BARR'E SYNDROME (ACUTE IDIOPATHIC POLYNEURITIS). Med Clin North Am. 1963 Sep;47:1371–1380. doi: 10.1016/s0025-7125(16)33540-4. [DOI] [PubMed] [Google Scholar]
- FEW J. D. A method for the analysis of urinary 17-hydroxycorticosteroids. J Endocrinol. 1961 Mar;22:31–46. doi: 10.1677/joe.0.0220031. [DOI] [PubMed] [Google Scholar]
- GEORGES R. J., SMALL N. A. The determination of 3-methoxy 4-hydroxy mandelic acid in urine. J Clin Pathol. 1962 Jul;15:388–389. doi: 10.1136/jcp.15.4.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hallpike J. F., Claveria L. E., Cohen N. M., Lascelles P. T. Glucose tolerance and plasma insulin levels in subarachnoid haemorrhage. Brain. 1971;94(1):151–164. doi: 10.1093/brain/94.1.151. [DOI] [PubMed] [Google Scholar]
- Jacobs H. S., Nabarro J. D. Plasma 11-hydroxycorticosteroid and growth hormone levels in acute medical illnesses. Br Med J. 1969 Jun 7;2(5657):595–598. doi: 10.1136/bmj.2.5657.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KOCEN R. S. Diabetes mellitus with acute polyneuritis. Br Med J. 1957 Jul 13;2(5036):100–101. doi: 10.1136/bmj.2.5036.100-d. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matsuyama H., Haymaker W. Distribution of lesions in the Landry-Guillain-Barré syndrome, with emphasis on involvement of the sympathetic system. Acta Neuropathol. 1967 May 5;8(3):230–241. doi: 10.1007/BF00688825. [DOI] [PubMed] [Google Scholar]
- Miller H. Polyneuritis. Br Med J. 1966 Nov 19;2(5524):1219–1225. doi: 10.1136/bmj.2.5524.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mitchell P. L., Meilman E. The mechanism of hypertension in the Guillain-Barré syndrome. Am J Med. 1967 Jun;42(6):986–995. doi: 10.1016/0002-9343(67)90079-4. [DOI] [PubMed] [Google Scholar]
- Van Vliet P. D., Burchell H. B., Titus J. L. Focal myocarditis associated with pheochromocytoma. N Engl J Med. 1966 May 19;274(20):1102–1108. doi: 10.1056/NEJM196605192742002. [DOI] [PubMed] [Google Scholar]