Table 2. Cox proportional hazard model.

	Discovery			Replication			Fixed effect meta analysis
Factor	HR	95% CI	p-value	HR	95% CI	P-value	HR	95% CI	P-value	Phet
RGMB	0.57	0.458–0.710	4.85E–07	0.62	0.381–1.007	0.05	0.61	0.5–0.74	8.11E–07	0.19
Age	1.95	1.150–3.317	0.13	1.30	0.535–3.169	0.56	1.69	1.07–2.66	0.02	0.29
Gender	0.94	0.559–1.585	0.82	0.90	0.370–2.2.5	0.82	0.94	0.6–1.49	0.81	0.98
Smoking status	0.94	0.615–1.445	0.79	0.62	0.234–1.639	0.34	0.92	0.62–1.36	0.68	0.78
Clinical stage	1.61	1.269–2.041	8.87E–05	1.92	1.216–3.045	0.01	1.55	1.25–1.91	5.38E–05	0.47