Table 2. Survival according to RUNX1 expression in the testing group of 157 CN-AML patients.
Outcome | All patients, n = 157 | ELN Favorable category | ELN Intermediate-I category | ||||||
---|---|---|---|---|---|---|---|---|---|
RUNX1high, n = 78 | RUNX1low, n = 79 | P | RUNX1high, n = 17 | RUNX1low, n = 18 | P | RUNX1high, n = 65 | RUNX1low, n = 57 | P | |
OS | |||||||||
Median OS, m | 10.46 (0.07–198.7) | 37.03 (0.13–214.5) | 0.009 | 58.91 (0.59–169.5) | 38.34 (0.3–214.5) | 0.65 | 8.41 (0.07–198.7) | 35.91 (0.13–190.3) | 0.002 |
Estimated OS at 3 y. % (95% CI) | 0.33 (0.24–0.46) | 0.54 (0.45–0.67) | 0.01 | 0.65 (0.46–0.92) | 0.56 (0.37–0.84) | 0.73 | 0.25 (0.16–0.38) | 0.54 (0.43–0.68) | 0.007 |
EFS | |||||||||
Median EFS, m | 7.1 (0.03–198.7) | 17.81 (0.03–214.5) | 0.011 | 39.82 (0.03–169.5) | 33.03 (0.03–214.5) | 0.36 | 6.57 (0.03–198.7) | 15.54 (0.03–190.3) | 0.004 |
Estimated EFS at 3 y. % (95% CI) | 0.28 (0.2–0.4) | 0.41 (0.31–0.53) | 0.005 | 0.53 (0.34–0.83) | 0.56 (0.37–0.84) | 0.17 | 0.2 (0.12–0.33) | 0.38 (0.27–0.52) | 0.03 |
CI, confidence interval.