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. 2016 Feb 16;7(13):15885–15900. doi: 10.18632/oncotarget.7419

Figure 5. Effects of WTD on the severity of arthritis in CIA rats.

Figure 5

A. Macroscopic performance of arthritis, including erythema and swelling, was clearly observed in the CIA CIA-cold/hot model groups, whereas doses of 3.75 g/(kg•day) WTD significantly ameliorated the development and severity of arthritis in SD rats in the CIA-cold model groups; B. Doses of 3.75 and 7.5 g/(kg•day) WTD significantly decreased the mean arthritis score in the CIA-cold model group; C. Low-high doses of WTD significantly decreased the arthritis incidence in a dose-dependent manner in the CIA-cold model groups; D. Doses of 3.75 and 7.5 g/(kg•day) WTD significantly delayed the time when arthritis first appeared in the CIA-cold model groups; E. Low-high doses of WTD significantly decreased the percentage of arthritis limbs in the CIA-cold model groups; WTD could also decrease the severity of arthritis in CIA rats in the CIA-hot model group without statistical significance. Data are represented as the mean±S.D. (n=16). *, **, and ***, P<0.05, P<0.01, and P<0.001, comparison with the control group. #, ##, ###, P<0.05, P<0.01, and P<0.001, comparison with the CIA model group. @, @@, @@@, P<0.05, P<0.01, and P<0.001, comparison with the CIA-cold/hot model groups.