Figure 4. Gene Ontology analyses were performed for protein-coding genes coexpressed with LCAL6.

A. Gene set enrichment analysis (GSEA) showed that LCAL6 were associated with important cellular function, like cell cycle, apoptosis, and adhesion B. Matrigel and transwell assays showed metastasis ability of A549 cell was significantly inhibited by silence of LCAL6 C. The percent of apoptotic cells were increased in LUAD cell lines after silence of LCAL6 D. as revealed by PI staining. And TUNEL assay confirmed the increased apoptosis in A549 cells.