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The potential CREB targeting site in SKA2 promoter, as detected by MultiTF tools (A). After down-regulation of CREB with siCREB, the mRNA (B) and protein (C) levels of SKA2 were significantly reduced in RCC cells. CHIP with specific CREB antibody showed binding of CREB to the putative promoter of SKA2 in RCC cell lines (D). Data were shown as mean ± SD from three independent experiments. *P < 0.05, **P < 0.01 versus siNC treatment.
