Table 5. Correlation between the clinicopathologic characteristics and HDAC3 expression (n = 84).
Clinicopathological parameters | No.of patients | Nuclear HDAC3 (n, %) | Cytoplasmic HDAC3 (n, %) | ||||
---|---|---|---|---|---|---|---|
Low | High | P-value | Low | High | P-value | ||
Cases | 84 | 38 (45.2) | 46 (54.8) | 38 (45.2) | 46 (54.8) | ||
Age (years) | |||||||
≤ 60 | 39 | 19 (48.7) | 20 (51.3) | 0.551a | 18 (46.2) | 21 (53.8) | 0.875a |
> 60 | 45 | 19 (42.2) | 26 (57.8) | 20 (44.4) | 25 (55.6) | ||
Gender | |||||||
Male | 51 | 20 (39.2) | 31 (60.8) | 0.168a | 25 (49.0) | 26 (51.0) | 0.387a |
Female | 33 | 18 (54.5) | 15 (45.5) | 13 (39.4) | 20 (60.6) | ||
Tumor location | |||||||
Head, neck | 56 | 23 (41.1) | 33 (58.9) | 0.278a | 26 (46.4) | 30 (53.6) | 0.757a |
Body, tail | 28 | 15 (53.6) | 13 (46.4) | 12 (42.9) | 16 (57.1) | ||
Tumor size (cm) | |||||||
≤ 3 | 25 | 10 (40.0) | 15 (60.0) | 0.530a | 12 (48.0) | 13 (52.0) | 0.741a |
> 3 | 59 | 28 (47.5) | 31 (52.5) | 26 (44.1) | 33 (55.9) | ||
Tumor differentiation | |||||||
Well, moderate | 57 | 27 (47.4) | 30 (52.6) | 0.569a | 26 (45.6) | 31 (54.4) | 0.920a |
Poor | 27 | 11 (40.7) | 16 (59.3) | 12 (44.4) | 15 (55.6) | ||
Invasion depth | |||||||
T1 + T2 | 71 | 35 (49.3) | 36 (50.7) | 0.081a | 29 (40.8) | 42 (59.2) | 0.059a |
T3 + T4 | 13 | 3 (23.1) | 10 (76.9) | 9 (69.2) | 4 (30.8) | ||
Lymph nodes metastasis | |||||||
N0 (negative) | 51 | 32 (62.7) | 19 (37.3) | < 0.001a* | 23 (45.1) | 28 (54.9) | 0.974a |
N1 (positive) | 33 | 6 (18.2) | 27 (81.8) | 15 (45.5) | 18 (54.5) | ||
Distant metastasis | |||||||
Absent | 82 | 38 (46.3) | 44 (53.7) | 0.499b | 36 (43.9) | 46 (56.1) | 0.202b |
Present | 2 | 0 (0) | 2 (100) | 2 (100) | 0 (0) | ||
Clinical stage | |||||||
Early stages (≤ IIa) | 49 | 31 (63.3) | 18 (36.7) | < 0.001a* | 22 (44.9) | 27 (55.1) | 0.941a |
Advanced stages (> IIa) | 35 | 7 (20.0) | 28 (80.0) | 16 (45.7) | 19 (54.3) | ||
Abdominal pain | |||||||
Absent | 38 | 16 (42.1) | 22 (57.9) | 0.600a | 19 (50.0) | 19 (50.0) | 0.425a |
Present | 46 | 22 (47.8) | 24 (52.2) | 19 (41.3) | 27 (58.7) | ||
Jaundice | |||||||
Absent | 69 | 33 (47.8) | 36 (52.2) | 0.307a | 31 (44.9) | 38 (55.1) | 0.902a |
Present | 15 | 5 (33.3) | 10 (66.7) | 7 (46.7) | 8 (53.3) | ||
Nervous invasion | |||||||
Negative | 51 | 19 (37.3) | 32 (62.7) | 0.068a | 26 (51.0) | 25 (49.0) | 0.189a |
Positive | 33 | 19 (57.6) | 14 (42.4) | 12 (36.4) | 21 (63.6) |
Chi-square test.
Fisher's exact test.
P < 0.05 indicates a significant association among the variables.