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. 2016 Mar 2;7(13):17194–17211. doi: 10.18632/oncotarget.7839

Figure 4.

Figure 4

Schedule for the experiment using Orthotropic SCID mouse model for 2 human thyroid cancer cell lines (8505c; ATC derived, and BCPAP; PTC derived cells) is outlined in A. In vivo results of PLX4720 treatment for both cell lines showing obvious tumor volume reduction B. PD-L1 mRNA expression of tumors pooled for each group showing significant reduction of PD-L1 (2 and 37 fold for 8505c and BCPAP respectively) when treated with PXL4720. C. IHC analysis for human PD-L1 showed a marked reduction of staining with PLX4720 treatment for both cell lines D.