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. 1981 Sep;34(9):991–995. doi: 10.1136/jcp.34.9.991

Fibre type changes in striated muscle of alcoholics

A Hanid 1,2, G Slavin 1,2, W Mair 1,2, C Sowter 1,2, P Ward 1,2, J Webb 1,2, J Levi 1,2
PMCID: PMC494218  PMID: 7276225

Abstract

Striated muscle from patients taking more than 80 g of alcohol each day shows selective atrophy of the type II fibres which are dependent on glycogenolytic pathways. This atrophy is associated with an excess of glycogen and lipid within the fibres and may represent a selective metabolic insult.

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Selected References

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  1. Brooke M. H., Engel W. K. The histographic analysis of human muscle biopsies with regard to fiber types. 1. Adult male and female. Neurology. 1969 Mar;19(3):221–233. doi: 10.1212/wnl.19.3.221. [DOI] [PubMed] [Google Scholar]
  2. EKBOM K., HED R., KIRSTEIN L., ASTROM K. E. MUSCULAR AFFECTIONS IN CHRONIC ALCOHOLISM. Arch Neurol. 1964 May;10:449–458. doi: 10.1001/archneur.1964.00460170019003. [DOI] [PubMed] [Google Scholar]
  3. Edström L., Nordemar R. Differential changes in type I and type II muscle fibres in rheumatoid arthritis. A biopsy study. Scand J Rheumatol. 1974;3(3):155–160. doi: 10.3109/03009747409097142. [DOI] [PubMed] [Google Scholar]
  4. Edwards R. H., Lewis P. D., Maunder C., Pearse A. G. Percutaneous needle biopsy in the diagnosis of muscle diseases. Lancet. 1973 Nov 10;2(7837):1070–1071. doi: 10.1016/s0140-6736(73)92672-x. [DOI] [PubMed] [Google Scholar]
  5. Häggmark T., Eriksson E. Cylinder or mobile cast brace after knee ligament surgery. A clinical analysis and morphologic and enzymatic studies of changes in the quadriceps muscle. Am J Sports Med. 1979 Jan-Feb;7(1):48–56. doi: 10.1177/036354657900700111. [DOI] [PubMed] [Google Scholar]
  6. Kiessling K. H., Pilström L., Bylund A. C., Piehl K., Saltin B. Effects of chronic ethanol abuse on structure and enzyme activities of skeletal muscle in man. Scand J Clin Lab Invest. 1975 Oct;35(6):601–607. doi: 10.1080/00365517509095786. [DOI] [PubMed] [Google Scholar]
  7. Klinkerfuss G., Bleisch V., Dioso M. M., Perkoff G. T. A spectrum of myopathy associated with alcoholism. II. Light and electron microscopic observations. Ann Intern Med. 1967 Sep;67(3):493–510. doi: 10.7326/0003-4819-67-3-493. [DOI] [PubMed] [Google Scholar]
  8. McKeran R. O., Slavin G., Andrews T. M., Ward P., Mair W. G. Muscle fibre type changes in hypothyroid myopathy. J Clin Pathol. 1975 Aug;28(8):659–663. doi: 10.1136/jcp.28.8.659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McKeran R. O., Slavin G., Ward P., Paul E., Mair W. G. Hypothyroid myopathy. A clinical and pathologaical study. J Pathol. 1980 Sep;132(1):35–54. doi: 10.1002/path.1711320105. [DOI] [PubMed] [Google Scholar]
  10. McKeran R. O., Ward P., Slavin G., Paul E. A. Central nuclear counts in muscle fibres before and during treatment in hypothyroid myopathy. J Clin Pathol. 1979 Mar;32(3):229–233. doi: 10.1136/jcp.32.3.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Oh S. J. Alcoholic myopathy, a critical review. Ala J Med Sci. 1972 Jan;9(1):79–95. [PubMed] [Google Scholar]
  12. Perkoff G. T. Alcoholic myopathy. Annu Rev Med. 1971;22:125–132. doi: 10.1146/annurev.me.22.020171.001013. [DOI] [PubMed] [Google Scholar]
  13. Pleasure D. E., Walsh G. O., Engel W. K. Atrophy of skeletal muscle in patients with Cushing's syndrome. Arch Neurol. 1970 Feb;22(2):118–125. doi: 10.1001/archneur.1970.00480200024002. [DOI] [PubMed] [Google Scholar]
  14. Rubin E. Alcoholic myopathy in heart and skeletal muscle. N Engl J Med. 1979 Jul 5;301(1):28–33. doi: 10.1056/NEJM197907053010107. [DOI] [PubMed] [Google Scholar]

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