Abstract
Colonisation of cerebrospinal fluid shunts by coagulate-negative staphylococci (Staphylococcus albus) is a serious problem. Because of its possible role in prevention of the condition, the antimicrobial activity of silicone rubber after impregnation with antimicrobial drugs was studied. The method of impregnation used and test methods were found to be important. Formaldehyde-urea condensates gave no activity. Gentamicin sulphate gave activity which was short-lived. Sodium and diethanolamine fusidates and clindamycin hydrochloride gave prolonged activity. A method of impregnation was developed which could be applied to commercially available shunts before use.
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Selected References
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- Bayston R. Antibiotic prophylaxis in shunt surgery. Dev Med Child Neurol Suppl. 1975;(35):99–103. doi: 10.1111/j.1469-8749.1975.tb03587.x. [DOI] [PubMed] [Google Scholar]
- Bayston R. Serological surveillance of children with CSF shunting devices. Dev Med Child Neurol Suppl. 1975;(35):104–110. doi: 10.1111/j.1469-8749.1975.tb03588.x. [DOI] [PubMed] [Google Scholar]
- Bayston R., Swinden J. The aetiology and prevention of shunt nephritis. Z Kinderchir Grenzgeb. 1979 Dec;28(4):377–384. [PubMed] [Google Scholar]
- Bayston R. The antibacterial effects of impregnated silastic and its possible applications in surgery. J Pediatr Surg. 1977 Feb;12(1):55–61. doi: 10.1016/0022-3468(77)90296-2. [DOI] [PubMed] [Google Scholar]
- HIGUCHI T. Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci. 1961 Oct;50:874–875. doi: 10.1002/jps.2600501018. [DOI] [PubMed] [Google Scholar]
- James H. E., Walsh J. W., Wilson H. D., Connor J. D., Bean J. R., Tibbs P. A. Prospective randomized study of therapy in cerebrospinal fluid shunt infection. Neurosurgery. 1980 Nov;7(5):459–463. doi: 10.1227/00006123-198011000-00006. [DOI] [PubMed] [Google Scholar]
- Welch K. Residual shunt infection in a program aimed at its prevention. Z Kinderchir Grenzgeb. 1979 Dec;28(4):374–377. [PubMed] [Google Scholar]
- van Noort R., Bayston R. Mechanical properties of antibacterial silicone rubber for hydrocephalus shunts. J Biomed Mater Res. 1979 Jul;13(4):623–630. doi: 10.1002/jbm.820130408. [DOI] [PubMed] [Google Scholar]