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. 1981 Oct;34(10):1076–1079. doi: 10.1136/jcp.34.10.1076

Localisation of immunoglobulin on the liver cell surface in primary biliary cirrhosis

K Krogsgaard 1,2,3, U Tage-Jensen 1,2,3, P Wantzin 1,2,3, J Aldershvile 1,2,3, F Hardt 1,2,3
PMCID: PMC494367  PMID: 7031093

Abstract

Direct immunofluorescence studies were performed on isolated liver cells in order to detect surface localisation of IgG in acute and chronic hepatitis and primary biliary cirrhosis. Membrane-bound IgG was demonstrated in nine patients. Six of eight patients with primary biliary cirrhosis showed granular fluorescence on their liver cell surfaces suggesting that an antibody or immune complex-mediated cytotoxicity might be involved in the pathogenesis of this disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alberti A., Realdi G., Tremolada F., Spina G. P. Liver cell surface localization of hepatitis B antigen and of immunoglobulins in acute and chronic hepatitis and in liver cirrhosis. Clin Exp Immunol. 1976 Sep;25(3):396–402. [PMC free article] [PubMed] [Google Scholar]
  2. Amoroso P., Vergani D., Wojcicka B. M., McFarlane I. G., Eddleston A. L., Tee D. E., Williams R. Identification of biliary antigens in circulating immune complexes in primary biliary cirrhosis. Clin Exp Immunol. 1980 Oct;42(1):95–98. [PMC free article] [PubMed] [Google Scholar]
  3. De Groote J., Desmet V. J., Gedigk P., Korb G., Popper H., Poulsen H., Scheuer P. J., Schmid M., Thaler H., Uehlinger E. A classification of chronic hepatitis. Lancet. 1968 Sep 14;2(7568):626–628. doi: 10.1016/s0140-6736(68)90710-1. [DOI] [PubMed] [Google Scholar]
  4. Geubel A. P., Keller R. H., Summerskill W. H., Dickson E. R., Tomasi T. B., Shorter R. G. Lymphocyte cytotoxicity and inhibition studied with autologous liver cells: observations in chronic active liver disease and the primary biliary cirrhosis syndrome. Gastroenterology. 1976 Sep;71(3):450–456. [PubMed] [Google Scholar]
  5. Gupta R. C., Dickson E. R., McDuffie F. C., Baggenstoss A. H. Circulating IgG complexes in primary biliary cirrhosis. A serial study in forty patients followed for two years. Clin Exp Immunol. 1978 Oct;34(1):19–27. [PMC free article] [PubMed] [Google Scholar]
  6. Hopf U., Arnold W., Meyer zum Büschenfelde K. H., Förster E., Bolte J. P. Studies on the pathogenesis of chronic inflammatory liver diseases. I. Membrane-fixed IgG on isolated hepatocytes from patients. Clin Exp Immunol. 1975 Oct;22(1):1–8. [PMC free article] [PubMed] [Google Scholar]
  7. Hopf U., Meyer zum Büschenfelde K. H., Arnold W. Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis. N Engl J Med. 1976 Mar 11;294(11):578–582. doi: 10.1056/NEJM197603112941103. [DOI] [PubMed] [Google Scholar]
  8. Manthorpe R., Permin H., Tage-Jensen U. Auto-antibodies in Sjögren's syndrome. With special reference to liver-cell membrane antibody (LMA). Scand J Rheumatol. 1979;8(3):168–172. doi: 10.3109/03009747909114450. [DOI] [PubMed] [Google Scholar]
  9. McFarlane I. G., Wojcicka B. M., Tsantoulas D. C., Portmann B. C., Eddleston A. L., Williams R. Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases. Gastroenterology. 1979 Jun;76(6):1333–1340. [PubMed] [Google Scholar]
  10. Sherlock S., Scheuer P. J. The presentation and diagnosis of 100 patients with primary biliary cirrhosis. N Engl J Med. 1973 Sep 27;289(13):674–678. doi: 10.1056/NEJM197309272891306. [DOI] [PubMed] [Google Scholar]
  11. Thomas H. C., Potter B. J., Sherlock S. Is primary biliary cirrhosis an immune complex disease? Lancet. 1977 Dec 17;2(8051):1261–1263. doi: 10.1016/s0140-6736(77)92666-6. [DOI] [PubMed] [Google Scholar]
  12. Trevisan A., Realdi G., Alberti A., Noventa F. Relationship between membrane-bound immunoglobulin and viral antigens in liver cells from patients with hepatitis B virus infection. Gastroenterology. 1979 Aug;77(2):209–214. [PubMed] [Google Scholar]
  13. Vierling J. M., Nelson D. L., Strober W., Bundy D. M., Jones E. A. In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis. Dysfunction of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis. J Clin Invest. 1977 Nov;60(5):1116–1128. doi: 10.1172/JCI108863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wands J. R., Dienstag J. L., Bhan A. K., Feller E. R., Isselbacher K. J. Circulating immune complexes and complement activation in primary biliary cirrhosis. N Engl J Med. 1978 Feb 2;298(5):233–237. doi: 10.1056/NEJM197802022980502. [DOI] [PubMed] [Google Scholar]

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