Erratum
After publication of the original article [1], it was noticed that the uncorrected version of this article was published which contained a typographical error within Tables 1 and 2. Within Table 1 the value “11.4 ± 4 03” incorrectly read as “114 ± 4 03”. Within Table 2 the value “46.9 ± 17” incorrectly read as “46 9 ± 17”. These errors do not in any way effect the results, findings, interpretation, conclusions, or the scientific basis of the paper. The correct versions of Tables 1 and 2 can be found below, and have been corrected in the original article.
Table 1.
Physiological parameters of mice on MR and CF diets. A 2-tailed t-test was conducted
| CF | MR | |||||
|---|---|---|---|---|---|---|
| Mean (g) SD | Mean (%) SD | N | Mean SD | Mean (%) SD | N | |
| Body weight | 26.6 ± 2.79 | 18 | 23.9 ± 2.3*** | 20 | ||
| Liver | 1.13 ± 0.15 | 4.35 ± 0.43 | 19 | 0.988 ± 0.13 ** | 4.15 ± 0.49 | 20 |
| Spleen | 0.102 ± 0.02 | 0.383 ± 0.07 | 19 | 0.104 ± 0.15 | 0.436 ± 0.59 | 20 |
| MFP (both) | 0.271 ± 0.06 | 1.01 ± 0.20 | 18 | 0.275 ± 0.10 | 1.13 ± 0.35 | 20 |
| Kidney (both) | 0.343 ± 0.04 | 1.33 ± 0.19 | 19 | 0.303 ± 0.05 ** | 1.27 ± 0.19 | 20 |
| Muscle-left side | 0.123 ± 0.02 | 0.475 ± 0.89 | 19 | 0.081 ± 0.03 **** | 0.339 ± 0.15 ** | 20 |
| Tumor-wt (mg) | 20.2 ± 6.1 a | 0.079 ± 0.30 | 15 | 11.4 ± 4 03 a **** | 0.049 ± 0.02*** | 20 |
**** p ≤ 0.0001, *** p ≤ 0.001, ** p ≤ 0.01
a tumor is in mg not g
Table 2.
Plasma amino acid concentrations from mice on MR and CF diets. Levels of methionine, cysteine, and taurine in the plasma from mice on the MR diet are significantly lower than those on the control diet. The Kruskal-Wallis test was used to analyze the differences in amino acid concentration
| CF | MR | |||
|---|---|---|---|---|
| Mean (nmol/mL) SD | N | Mean (nmol/mL) SD | N | |
| Ala | 398 ± 85 | 17 | 520 ± 122 *** | 18 |
| Arg | 133 ± 29 | 17 | 117 ± 21 | 18 |
| Asp | 11.8 ± 4.9 | 16 | 10.3 ± 3.1 | 18 |
| Cys | 4.39 ± 2.4 | 13 | 2.22 ± 0.44 * | 9 |
| Gln | 622 ± 89 | 17 | 812 ± 106**** | 18 |
| Glu | 106 ± 20 | 17 | 117 ± 19 | 18 |
| His | 88.8 ± 11 | 17 | 112 ± 20*** | 18 |
| Ile | 94.8 ± 32 | 17 | 108 ± 27 | 18 |
| Leu | 139 ± 47 | 17 | 180 ± 46** | 18 |
| Met | 248 ± 125 | 17 | 46.9 ± 17**** | 18 |
| Orn | 62.7 ± 29 | 17 | 114 ± 41*** | 18 |
| Phe | 114 ± 42 | 17 | 132 ± 39 | 18 |
| Pro | 69.5 ± 8.6 | 17 | 82.4 ± 34 | 18 |
| Ser | 218 ± 34 | 17 | 339 ± 84**** | 18 |
| Tau | 226 ± 50 | 17 | 77.1 ± 35**** | 18 |
| Thr | 346 ± 94 | 17 | 383 ± 136 | 18 |
| Tyr | 89.5 ± 19 | 17 | 107 ± 28* | 18 |
| Trp | 130 ± 29 | 17 | 128 ± 29 | 18 |
**** p ≤ 0.0001, *** p ≤ 0.001, ** p ≤ 0.01, * p ≤ 0.05
Footnotes
The online version of the original article can be found under doi:10.1186/s12885-016-2367-1.
References
- 1.Hens JR, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, et al. Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer. 2016;16:349. doi: 10.1186/s12885-016-2367-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
