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. 2016 Jul 14;16:474. doi: 10.1186/s12885-016-2404-0

Erratum to: Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

J R Hens 1,, I Sinha 2, F Perodin 1, T Cooper 3, R Sinha 2, J Plummer 1, C E Perrone 1, D Orentreich 1
PMCID: PMC4944442  PMID: 27417544

Erratum

After publication of the original article [1], it was noticed that the uncorrected version of this article was published which contained a typographical error within Tables 1 and 2. Within Table 1 the value “11.4 ± 4 03” incorrectly read as “114 ± 4 03”. Within Table 2 the value “46.9 ± 17” incorrectly read as “46 9 ± 17”. These errors do not in any way effect the results, findings, interpretation, conclusions, or the scientific basis of the paper. The correct versions of Tables 1 and 2 can be found below, and have been corrected in the original article.

Table 1.

Physiological parameters of mice on MR and CF diets. A 2-tailed t-test was conducted

CF MR
Mean (g) SD Mean (%) SD N Mean SD Mean (%) SD N
Body weight 26.6 ± 2.79 18 23.9 ± 2.3*** 20
Liver 1.13 ± 0.15 4.35 ± 0.43 19 0.988 ± 0.13 ** 4.15 ± 0.49 20
Spleen 0.102 ± 0.02 0.383 ± 0.07 19 0.104 ± 0.15 0.436 ± 0.59 20
MFP (both) 0.271 ± 0.06 1.01 ± 0.20 18 0.275 ± 0.10 1.13 ± 0.35 20
Kidney (both) 0.343 ± 0.04 1.33 ± 0.19 19 0.303 ± 0.05 ** 1.27 ± 0.19 20
Muscle-left side 0.123 ± 0.02 0.475 ± 0.89 19 0.081 ± 0.03 **** 0.339 ± 0.15 ** 20
Tumor-wt (mg) 20.2 ± 6.1 a 0.079 ± 0.30 15 11.4 ± 4 03 a **** 0.049 ± 0.02*** 20

**** p ≤ 0.0001, *** p ≤ 0.001, ** p ≤ 0.01

a tumor is in mg not g

Table 2.

Plasma amino acid concentrations from mice on MR and CF diets. Levels of methionine, cysteine, and taurine in the plasma from mice on the MR diet are significantly lower than those on the control diet. The Kruskal-Wallis test was used to analyze the differences in amino acid concentration

CF MR
Mean (nmol/mL) SD N Mean (nmol/mL) SD N
Ala 398 ± 85 17 520 ± 122 *** 18
Arg 133 ± 29 17 117 ± 21 18
Asp 11.8 ± 4.9 16 10.3 ± 3.1 18
Cys 4.39 ± 2.4 13 2.22 ± 0.44 * 9
Gln 622 ± 89 17 812 ± 106**** 18
Glu 106 ± 20 17 117 ± 19 18
His 88.8 ± 11 17 112 ± 20*** 18
Ile 94.8 ± 32 17 108 ± 27 18
Leu 139 ± 47 17 180 ± 46** 18
Met 248 ± 125 17 46.9 ± 17**** 18
Orn 62.7 ± 29 17 114 ± 41*** 18
Phe 114 ± 42 17 132 ± 39 18
Pro 69.5 ± 8.6 17 82.4 ± 34 18
Ser 218 ± 34 17 339 ± 84**** 18
Tau 226 ± 50 17 77.1 ± 35**** 18
Thr 346 ± 94 17 383 ± 136 18
Tyr 89.5 ± 19 17 107 ± 28* 18
Trp 130 ± 29 17 128 ± 29 18

**** p ≤ 0.0001, *** p ≤ 0.001, ** p ≤ 0.01, * p ≤ 0.05

Footnotes

The online version of the original article can be found under doi:10.1186/s12885-016-2367-1.

References

  • 1.Hens JR, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, et al. Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer. 2016;16:349. doi: 10.1186/s12885-016-2367-1. [DOI] [PMC free article] [PubMed] [Google Scholar]

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