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. 1973 Oct;36(5):724–735. doi: 10.1136/jnnp.36.5.724

Cerebrovascular response to intracarotid injection of serotonin before and after middle cerebral artery occlusion 1

K M A Welch 1,2, Kazuo Hashi 1,2, John Stirling Meyer 1,2
PMCID: PMC494449  PMID: 4201867

Abstract

The effect of intracarotid injection of serotonin (5-HT) on internal carotid artery flow and oxygen availability (O2a) of the cerebral cortex was studied in 10 baboons. Vasoconstriction occurred in the vascular bed of the territory supplied by the injected artery. After one middle cerebral artery was occluded the vasoconstrictor effect of 5-HT was more pronounced, particularly in the non-ischaemic hemisphere. The capacity of the cerebral vessels to provide collateral blood flow was reduced in both ischaemic and non-ischaemic areas of brain. As a result of focal cerebral ischaemia, 5-HT may accumulate in the brain and contribute to the progression of infarction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames A., 3rd, Wright R. L., Kowada M., Thurston J. M., Majno G. Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol. 1968 Feb;52(2):437–453. [PMC free article] [PubMed] [Google Scholar]
  2. Arutiunov A. I., Baron M. A., Majorova N. A. Experimental and clinical study of the development of spasm of the cerebral arteries related to subarachnoid hemorrhage. J Neurosurg. 1970 Jun;32(6):617–625. doi: 10.3171/jns.1970.32.6.0617. [DOI] [PubMed] [Google Scholar]
  3. BOHR D. F., GOULET P. L., TAQUINI A. C., Jr Direct tension recording from smooth muscle of resistance vessels from various organs. Angiology. 1961 Oct;12:478–485. doi: 10.1177/000331976101201009. [DOI] [PubMed] [Google Scholar]
  4. BULLE P. H. Effects of reserpine and chlorpromazine in prevention of cerebral edema and reversible cell damage. Proc Soc Exp Biol Med. 1957 Mar;94(3):553–556. doi: 10.3181/00379727-94-23010. [DOI] [PubMed] [Google Scholar]
  5. Bell W. H., 3rd, Sundt T. M., Jr, Nofzinger J. D. The response of cortical vessels to serotonin in experimental cerebral infarction. J Neurosurg. 1967 Feb;26(2):203–212. doi: 10.3171/jns.1967.26.2.0203. [DOI] [PubMed] [Google Scholar]
  6. Brawley B. W., Strandness D. E., Jr, Kelly W. A. The biphasic response of cerebral vasospasm in experimental subarachnoid hemorrhage. J Neurosurg. 1968 Jan;28(1):1–8. doi: 10.3171/jns.1968.28.1.0001. [DOI] [PubMed] [Google Scholar]
  7. Brodie B. B., Reid W. D. Serotonin in brain: functional considerations. Adv Pharmacol. 1968;6(Pt B Suppl):97–113. doi: 10.1016/s1054-3589(08)60300-2. [DOI] [PubMed] [Google Scholar]
  8. CLARK L. C., Jr, MISRAHY G., FOX R. P. Chronically implanted polarographic electrodes. J Appl Physiol. 1958 Jul;13(1):85–91. doi: 10.1152/jappl.1958.13.1.85. [DOI] [PubMed] [Google Scholar]
  9. COSTA E., RINALDI F. Biochemical and electroencephalographic changes in the brain of rabbits injected with 5-hydroxytryptophan (influence of chlorpromazine premedication). Am J Physiol. 1958 Jul;194(1):214–220. doi: 10.1152/ajplegacy.1958.194.1.214. [DOI] [PubMed] [Google Scholar]
  10. DENNY-BROWN D., MEYER J. S. The cerebral collateral circulation. II. Production of cerebral infarction by ischemic anoxia and its reversibility in early stages. Neurology. 1957 Aug;7(8):567–579. doi: 10.1212/wnl.7.8.567. [DOI] [PubMed] [Google Scholar]
  11. DOMER F. R., LONGO V. G. Effect of 5-hydroxytryptophan on the cerebral electrical activity of the rabbit. Arch Int Pharmacodyn Ther. 1962 Mar 1;136:204–218. [PubMed] [Google Scholar]
  12. Echlin F. A. Spasm of basilar and vertebral arteries caused by experimental subarachnoid hemorrhage. J Neurosurg. 1965 Jul;23(1):1–11. doi: 10.3171/jns.1965.23.1.0001. [DOI] [PubMed] [Google Scholar]
  13. GADDUM J. H., VOGT M. Some central actions of 5-hydroxytryptamine and various antagonists. Br J Pharmacol Chemother. 1956 Jun;11(2):175–179. doi: 10.1111/j.1476-5381.1956.tb01049.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Grimson B. S., Robinson S. C., Danford E. T., Tindall G. T., Greenfield J. C., Jr Effect of serotonin on internal and external carotid artery blood flow in the baboon. Am J Physiol. 1969 Jan;216(1):50–55. doi: 10.1152/ajplegacy.1969.216.1.50. [DOI] [PubMed] [Google Scholar]
  15. HOEDT-RASMUSSEN K., SKINHOJ E. TRANSNEURAL DEPRESSION OF THE CEREBRAL HEMISPHERIC METABOLISM IN MAN. Acta Neurol Scand. 1964;40:41–46. doi: 10.1111/j.1600-0404.1964.tb04264.x. [DOI] [PubMed] [Google Scholar]
  16. Halsey J. H., Jr, Clark L. C., Jr Some regional circulatory abnormalities following experimental cerebral infarction. Neurology. 1970 Mar;20(3):238–246. doi: 10.1212/wnl.20.3.238. [DOI] [PubMed] [Google Scholar]
  17. Hudgins W. R., Garcia J. H. Transorbital approach to the middle cerebral artery of the squirrel monkey: a technique for experimental cerebral infarction applicable to ultrastructural studies. Stroke. 1970 Mar-Apr;1(2):107–111. doi: 10.1161/01.str.1.2.107. [DOI] [PubMed] [Google Scholar]
  18. KARLSBERG P., ELLIOTT H. W., ADAMS J. E. EFFECT OF VARIOUS PHARMACOLOGIC AGENTS ON CEREBRAL ARTERIES. Neurology. 1963 Sep;13:772–778. doi: 10.1212/wnl.13.9.772. [DOI] [PubMed] [Google Scholar]
  19. KRIEGER D. T., KOLODNY H. D., WARNER R. R. SERUM SEROTONIN IN NERVOUS SYSTEM DISEASE. Neurology. 1964 Jun;14:578–580. doi: 10.1212/wnl.14.6.578. [DOI] [PubMed] [Google Scholar]
  20. LENDE R. A. Local spasm in cerebral arteries. J Neurosurg. 1960 Jan;17:90–103. doi: 10.3171/jns.1960.17.1.0090. [DOI] [PubMed] [Google Scholar]
  21. Lance J. W., Anthony M. The effect of serotonin on cranial vessels and its significance in migraine. Proc Aust Assoc Neurol. 1968;5(3):639–642. [PubMed] [Google Scholar]
  22. MAJNO G., PALADE G. E. Studies on inflammation. 1. The effect of histamine and serotonin on vascular permeability: an electron microscopic study. J Biophys Biochem Cytol. 1961 Dec;11:571–605. doi: 10.1083/jcb.11.3.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. MARRAZZI A. S., HART E. R. Relationship of hallucinogens to adrenergic cerebral neurohumors. Science. 1955 Mar 11;121(3141):365–367. doi: 10.1126/science.121.3141.365. [DOI] [PubMed] [Google Scholar]
  24. MEYER J. S., DENNY-BROWN D. The cerebral collateral circulation. I. Factors influencing collateral blood flow. Neurology. 1957 Jul;7(7):447–458. doi: 10.1212/wnl.7.7.447. [DOI] [PubMed] [Google Scholar]
  25. MEYER J. S., FANG H. C., DENNY-BROWN D. Polarographic study of cerebral collateral circulation. AMA Arch Neurol Psychiatry. 1954 Sep;72(3):296–312. doi: 10.1001/archneurpsyc.1954.02330030030003. [DOI] [PubMed] [Google Scholar]
  26. MEYER J. S. Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction. N Engl J Med. 1958 Jan 23;258(4):151–159. doi: 10.1056/NEJM195801232580401. [DOI] [PubMed] [Google Scholar]
  27. MONNIER M. [Electrophysiological actions of stimulants of the central nervous system. I. Adrenergic, cholinergic systems and serotonic neurohumors]. Arch Int Pharmacodyn Ther. 1960 Mar 1;124:281–301. [PubMed] [Google Scholar]
  28. Meyer J. S., Shinohara Y., Kanda T., Fukuuchi Y., Ericsson A. D., Kok N. K. Diaschisis resulting from acute unilateral cerebral infarction. Quantitative evidence for man. Arch Neurol. 1970 Sep;23(3):241–247. doi: 10.1001/archneur.1970.00480270051007. [DOI] [PubMed] [Google Scholar]
  29. Misra S. S., Singh K. S., Bhargava K. P. Estimation of 5-hydroxytryptamine (5-HT) level in cerebrospinal fluid of patients with intracranial or spinal lesions. J Neurol Neurosurg Psychiatry. 1967 Apr;30(2):163–165. doi: 10.1136/jnnp.30.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Osterholm J. L., Meyer R. Experimental effects of free serotonin on the brain and its relation to brain injury. 2. Trauma-induced alterations in spinal fluid and brain. J Neurosurg. 1969 Oct;31(4):413–416. [PubMed] [Google Scholar]
  31. Osterholm J. L., Pyenson J. Experimental effects of free serotonin on the brain and its relation to brain injury. 3. Serotonin-induced cerebral edema. J Neurosurg. 1969 Oct;31(4):417–421. [PubMed] [Google Scholar]
  32. Păuşescu E., Lugojan R., Păuşescu M. Cerebral catecholamine and serotonin metabolism in post-hypothermic brain oedema. Brain. 1970;93(1):31–36. doi: 10.1093/brain/93.1.31. [DOI] [PubMed] [Google Scholar]
  33. RAYNOR R. B., McMURTRY J. G., POOL J. L. Cerebrovascular effects of topically applied serotonin in the cat. Neurology. 1961 Mar;11:190–195. doi: 10.1212/wnl.11.3.190. [DOI] [PubMed] [Google Scholar]
  34. Rosenblum W. I. Neurogenic control of cerebral circulation. Stroke. 1971 Sep-Oct;2(5):429–439. doi: 10.1161/01.str.2.5.429. [DOI] [PubMed] [Google Scholar]
  35. SOUTHERN A. L., CHRISTOFF N. Cerebrospinal fluid serotonin in brain tumor and other neurological disorders determined by a spectrophotofluorometric technique. J Lab Clin Med. 1962 Feb;59:320–326. [PubMed] [Google Scholar]
  36. SYMON L., ISHIKAWA S., MEYER J. S. Cerebral arterial pressure changes and development of leptomeningeal collateral circulation. Neurology. 1963 Mar;13:237–250. doi: 10.1212/wnl.13.3.237. [DOI] [PubMed] [Google Scholar]
  37. Simeone F. A., Ryan K. G., Cotter J. R. Prolonged experimental cerebral vasospasm. J Neurosurg. 1968 Oct;29(4):357–366. doi: 10.3171/jns.1968.29.4.0357. [DOI] [PubMed] [Google Scholar]
  38. Stoica E., Nash F. Angiographic investigations on the reactivity of the cerebral vessels to cold stress in cerebrovascular disease. Neurology. 1966 Dec;16(12):1177–1184. doi: 10.1212/wnl.16.12.1177. [DOI] [PubMed] [Google Scholar]
  39. Waltz A. G., Sundt T. M., Jr The microvasculature and microcirculation of the cerebral cortex after arterial occlusion. Brain. 1967 Sep;90(3):681–696. doi: 10.1093/brain/90.3.681. [DOI] [PubMed] [Google Scholar]
  40. Welch K. M., Meyer J. S., Kwant S. Estimation of levels of serotonin and 5-hydroxyindoles in whole blood by an autoanalytical procedure: observations on the blood-brain barrier. J Neurochem. 1972 Apr;19(4):1079–1087. doi: 10.1111/j.1471-4159.1972.tb01428.x. [DOI] [PubMed] [Google Scholar]
  41. Welch K. M., Meyer J. S., Teraura T., Hashi K., Shinmaru S. Ischemic anoxia and cerebral serotonin levels. J Neurol Sci. 1972 May;16(1):85–92. doi: 10.1016/0022-510x(72)90103-7. [DOI] [PubMed] [Google Scholar]
  42. Wilkins R. H., Odom G. L. Intracranial arterial spasm associated with craniocerebral trauma. J Neurosurg. 1970 Jun;32(6):626–633. doi: 10.3171/jns.1970.32.6.0626. [DOI] [PubMed] [Google Scholar]
  43. Wilkins R. H., Silver D., Odom G. L. The role of circulating substances in intracranial arterial spasm. I. Serotonin and histamine. Neurology. 1966 May;16(5):482–490. doi: 10.1212/wnl.16.5.482. [DOI] [PubMed] [Google Scholar]

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