Abstract
Chronic cyanide intoxication of dietary origin and riboflavine deficiency are believed to be major aetiological factors in Nigerian tropical ataxic neuropathy. The results are presented of a double-blind controlled therapeutic trial of combinations of large doses of hydroxocobalamin and cystine as cyanide binding agents together with riboflavine or placebos in Nigerian patients suffering from the tropical ataxic neuropathy. No clinical benefit was demonstrable with any of the treatments.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Makene W. J., Wilson J. Biochemical studies in Tanzanian patients with ataxic tropical neuropathy. J Neurol Neurosurg Psychiatry. 1972 Feb;35(1):31–33. doi: 10.1136/jnnp.35.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Monekosso G. L., Wilson J. Plasma thiocyanate and vitamin B12 in Nigerian patients with degenerative neurological disease. Lancet. 1966 May 14;1(7446):1062–1064. doi: 10.1016/s0140-6736(66)91009-9. [DOI] [PubMed] [Google Scholar]
- Osuntokun B. O. An ataxic neuropathy in Nigeria. A clinical, biochemical and electrophysiological study. Brain. 1968 Jun;91(2):215–248. doi: 10.1093/brain/91.2.215. [DOI] [PubMed] [Google Scholar]
- Osuntokun B. O., Durowoju J. E., McFarlane H., Wilson J. Plasma amino-acids in the Nigerian nutritional ataxic neuropathy. Br Med J. 1968 Sep 14;3(5619):647–649. doi: 10.1136/bmj.3.5619.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Osuntokun B. O. Epidemiology of tropical nutritional neuropathy in Nigerians. Trans R Soc Trop Med Hyg. 1971;65(4):454–479. doi: 10.1016/0035-9203(71)90156-8. [DOI] [PubMed] [Google Scholar]
- Osuntokun B. O., Langman M. J., Wilson J., Aladetoyinbo A. Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy. J Neurol Neurosurg Psychiatry. 1970 Oct;33(5):663–666. doi: 10.1136/jnnp.33.5.663. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Osuntokun B. O., Monekosso G. L., Wilson J. Relationship of a degenerative tropical neuropathy to diet: report of a field survey. Br Med J. 1969 Mar 1;1(5643):547–550. doi: 10.1136/bmj.1.5643.547. [DOI] [PMC free article] [PubMed] [Google Scholar]