Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1974 Jan;37(1):108–111. doi: 10.1136/jnnp.37.1.108

A case of Noonan's syndrome and hypoparathyroidism presenting with epilepsy

Peter Rudge 1, B G R Neville 1, P T Lascelles 1
PMCID: PMC494571  PMID: 4544321

Abstract

A patient of 29 years is described with Noonan's syndrome and idiopathic hypoparathyroidism, who presented with epilepsy and myoclonus. Correction of the hypocalcaemia resulted in improvement of his myoclonus and psychiatric abnormalities. The embryological significance of the association is discussed.

Full text

PDF
108

Images in this article

109Image
on p.109
109Image
on p.109
109Image
on p.109

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRONSKY D., KUSHNER D. S., DUBIN A., SNAPPER I. [Idiopathic hypoparathyroidism and pseudohypoparathyroidism: case reports and review of the literature]. Medicine (Baltimore) 1958 Dec;37(4):317–352. doi: 10.1097/00005792-195812000-00003. [DOI] [PubMed] [Google Scholar]
  2. Basser L. S., Neale F. C., Ireland A. W., Posen S. Epilepsy and electroencephalographic abnormalities in chronic surgical hypoparathyroidism. Ann Intern Med. 1969 Sep;71(3):507–515. doi: 10.7326/0003-4819-71-3-507. [DOI] [PubMed] [Google Scholar]
  3. FOURMAN P., DAVIS R. H., JONES K. H., MORGAN D. B., SMITH J. W. Parathyroid insufficiency after thyroidectomy. Review of 46 patients with a study of the effects of hypocalcaemia on the electro-encephalogram. Br J Surg. 1963 May;50:608–619. doi: 10.1002/bjs.18005022410. [DOI] [PubMed] [Google Scholar]
  4. GLASER G. H., LEVY L. Seizures and idiopathic hypoparathyroidism. A clinical-electroencephalographic study. Epilepsia. 1960 Jun;1:454–465. doi: 10.1111/j.1528-1157.1959.tb04280.x. [DOI] [PubMed] [Google Scholar]
  5. HODGKINSON A. Renal phosphate excretion indices in the diagnosis of hyperparathyroidism. Clin Sci. 1961 Aug;21:125–132. [PubMed] [Google Scholar]
  6. Noonan J. A. Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease. Am J Dis Child. 1968 Oct;116(4):373–380. doi: 10.1001/archpedi.1968.02100020377005. [DOI] [PubMed] [Google Scholar]
  7. Pergament E., Pietra G. C., Kadotani T., Sato H., Berlow S. A ring chromosome No. 16 in an infant with primary hypoparathyroidism. J Pediatr. 1970 May;76(5):745–751. doi: 10.1016/s0022-3476(70)80295-5. [DOI] [PubMed] [Google Scholar]
  8. ROBINSON P. K., CARMICHAEL E. A., CUMINGS J. N. Idiopathic hypoparathyroidism; a study of three cases. Q J Med. 1954 Oct;23(92):383–402. [PubMed] [Google Scholar]
  9. SUGAR O. Central neurological complications of hypoparathyroidism. AMA Arch Neurol Psychiatry. 1953 Jul;70(1):86–107. doi: 10.1001/archneurpsyc.1953.02320310092008. [DOI] [PubMed] [Google Scholar]
  10. Tuvemo T., Gustavson K. H. Idiopathic hypoparathyroidism in a girl with Turner's syndrome. Acta Paediatr Scand. 1972 Nov;61(6):724–728. doi: 10.1111/j.1651-2227.1972.tb15976.x. [DOI] [PubMed] [Google Scholar]
  11. VAN DER WERFF TEN BOSCH J. J. The syndrome of brachymetacarpal dwarfism (pseudo-pseudohypoparathyroidism) with and without gonadal dysgenesis. Lancet. 1959 Jan 10;1(7063):69–71. doi: 10.1016/s0140-6736(59)91137-7. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES