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. 2016 May 30;5(5):e226. doi: 10.1038/oncsis.2016.32

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Copyright © 2016 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Combined ROR1 and ROR2 silencing sensitises A2780-cis cells to cisplatin. (a) ROR1 knockdown has no effect on cell viability when treated with cisplatin. Results represent an average of three experiments. Error bars represent the s.d. of the mean. (b) ROR2 knockdown has no effect on cell viability when treated with cisplatin. Results represent an average of three experiments. Error bars represent the s.d. of the mean. (c) Simultaneous ROR1 and ROR2 knockdown decreases A2780-cis chemoresistance and was significant at three concentration points using silencers set A. Significance was determined only between the black (negative control) and grey (ROR1- and ROR2-silenced) cells. The dotted line indicates chemosensitivity of the A2780 cell line for comparison. A2780-cis Results represent an average of three experiments. A2780 results represent an average of two experiments. Error bars represent the s.d. of the mean. *P<0.05. (d) Simultaneous ROR1 and ROR2 knockdown decreases A2780-cis chemoresistance using silencers set B, however, is not statistically significant. A2780-cis results represent an average of three experiments. Error bars represent the s.d. of the mean.