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. 2016 May 9;5(5):e222. doi: 10.1038/oncsis.2016.33

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Copyright © 2016 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Chondrosarcoma cell lines are sensitive to YM155, which is p53 dependent. (a) JJ012 cell line showing strong survivin expression. (b) Normalized RNA expression of three survivin isoforms in eight chondrosarcoma cell lines. JJ012, SW1353 and L835 show a clear reduction in survivin expression after YM155 treatment. Growth plate and cartilage are taken as a control. Bars represent mean with standard deviation. (c, d) Dose response curves for YM155 (72 h) in conventional subtypes (c) and rare chondrosarcoma subtypes (d). Error bars are shown for three experiments performed in triplicate. (e) IC₅₀s determined for TP53 wt and mutant cell lines showing a significantly increased sensitivity of TP53 mutant cell lines toward YM155. Bars represent mean values of three experiments performed in triplicate.