Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1974 Feb;37(2):181–190. doi: 10.1136/jnnp.37.2.181

Electroencephalographic seizures during cardiopulmonary bypass

J Stockard 1,2,3, P Calanchini 1,2,3, R Bickford 1,2,3, T Billinger 1,2,3
PMCID: PMC494604  PMID: 4819907

Abstract

Eleven cardiac operations are reported in which there was electroencephalographic and/or clinical evidence of seizure activity during cardiopulmonary bypass (CPB). In four patients seizure activity appeared after acute episodes of cerebral ischaemia resulting from either hypotension or pump-generated emboli occurring at the beginning of CPB, or from air embolism occurring at the end of CPB when the myocardium was closed and defibrillated. In the remaining seven patients the seizures appeared to result from the synergistic action of a toxic substance in the perfusate with pre-existing or CPB-induced alterations in cerebral physiology.

Full text

PDF
181

Images in this article

183Image
on p.183
184Image
on p.184
185Image
on p.185
186Image
on p.186

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames R. H. Ventriculo-peritoneal shunts in the management of hydrocephalus. J Neurosurg. 1967 Dec;27(6):525–529. doi: 10.3171/jns.1967.27.6.0525. [DOI] [PubMed] [Google Scholar]
  2. Arfel G., Casanova C., Naquet R., Passelecq J., Dubost C. Etude électro-clinique de l'embolie gazeuse cérébrale en chirurgie cardiaque. Electroencephalogr Clin Neurophysiol. 1967 Aug;23(2):101–122. doi: 10.1016/0013-4694(67)90101-0. [DOI] [PubMed] [Google Scholar]
  3. Carmen R., Kahn P. Test in vitro of silicone rubber heart-valve poppets for lipid absorption. J Assoc Adv Med Instrum. 1969 Jan;3(1 Pt 1):14–17. [PubMed] [Google Scholar]
  4. Dobell A. R., Wyant J. D., Seamans K. B., Gloor P. Penicillin epilepsy. Studies on the blood-brain barrier during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1966 Oct;52(4):469–475. [PubMed] [Google Scholar]
  5. Ducker T. B., Hayes G. J. Experimental improvements in the use of Silastic cuff for peripheral nerve repair. J Neurosurg. 1968 Jun;28(6):582–587. doi: 10.3171/jns.1968.28.6.0582. [DOI] [PubMed] [Google Scholar]
  6. GASTAUT H., NAQUET R., FISCHERWILLIAMS M. The pathophysiology of grand mal seizures generalized from the start. J Nerv Ment Dis. 1958 Jul;127(1):21–33. doi: 10.1097/00005053-195807000-00004. [DOI] [PubMed] [Google Scholar]
  7. Hine C. H., Elliott H. W., Wright R. R., Cavalli R. D., Porter C. D. Evaluation of a silicone lubricant injected spinally. Toxicol Appl Pharmacol. 1969 Nov;15(3):566–573. doi: 10.1016/0041-008x(69)90059-3. [DOI] [PubMed] [Google Scholar]
  8. Juneja I., Flynn R. E., Berger R. L. The arterial, venous pressures and the electroencephalogram during open heart sugery. Acta Neurol Scand. 1972;48(2):163–168. doi: 10.1111/j.1600-0404.1972.tb07537.x. [DOI] [PubMed] [Google Scholar]
  9. KAVAN E. M., BRECHNER V. L., WALTER R. D., MALONEY J. V. Electroencephalographic patterns during intracardiac surgery using cardiopulmonary bypass; a comparison of two anesthetic agents. AMA Arch Surg. 1959 Jan;78(1):151–156. doi: 10.1001/archsurg.1959.04320010153025. [DOI] [PubMed] [Google Scholar]
  10. Lawrence R. M. Hypotension: its relation to epilepsy. Int J Neuropsychiatry. 1966 Apr;2(2):157–159. [PubMed] [Google Scholar]
  11. Lorenz R., Hehrlein F. Electroencephalographic findings in heart surgery. Minn Med. 1970 Oct;53(10):1069–1076. [PubMed] [Google Scholar]
  12. Mukai N. [Silicone oil (dimethylpolysiloxane) and nerve tissue damage--pathogenesis of silicone retinopathy as an example]. No To Shinkei. 1971 Jul;23(7):793–803. [PubMed] [Google Scholar]
  13. Radvanyi M. F., Leon L., Dreyfus-Brisac C. E.E.G. en chirurgie cardiaque. Surveillance de 80 opérés. Rev Neurol (Paris) 1969 Sep;121(3):244–246. [PubMed] [Google Scholar]
  14. Radvanyi M. F., Leon L., Dreyfus-Brisac C. EEG in cardiac surgery: survey of 80 cases. Electroencephalogr Clin Neurophysiol. 1970 Jun;28(6):644–645. [PubMed] [Google Scholar]
  15. Seamans K. B., Gloor P., Dobell R. A., Wyant J. D. Penicillin-induced seizures during cardiopulmonary bypass. A clinical and electroencephalographic study. N Engl J Med. 1968 Apr 18;278(16):861–868. doi: 10.1056/NEJM196804182781601. [DOI] [PubMed] [Google Scholar]
  16. Stockard J. J., Bickford R. G., Schauble J. F. Pressure-dependent cerebral ischemia during cardiopulmonary bypass. Neurology. 1973 May;23(5):521–529. doi: 10.1212/wnl.23.5.521. [DOI] [PubMed] [Google Scholar]
  17. THEYE R. A., PATRICK R. T., KIRKLIN J. W. The electro-encephalogram in patients undergoing open intracardiac operations with the aid of extracorporeal circulation. J Thorac Surg. 1957 Dec;34(6):709–717. [PubMed] [Google Scholar]
  18. VAN BERGEN F. H., BUCKLEY J. J., FRENCH L. A., DOBKIN A. B., BROWN I. A. Physiologic alterations associated with hexamethonium-induced hypotension. Anesthesiology. 1954 Sep;15(5):507–536. doi: 10.1097/00000542-195409000-00010. [DOI] [PubMed] [Google Scholar]
  19. Weiss S. R., Raskind R. Twenty-two cases of hydrocephalus treated with a silastic ventriculoperitoneal shunt. Int Surg. 1969 Jan;51(1):13–19. [PubMed] [Google Scholar]
  20. Wright J. S., Lethlean A. K., Hicks R. G., Torda T. A., Stacey R. Electroencephalographic studies during open-heart surgery. J Thorac Cardiovasc Surg. 1972 Apr;63(4):631–638. [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES