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. 2016 Mar 16;41(9):2283–2293. doi: 10.1038/npp.2016.27

Figure 2.

Figure 2

Rimonabant or AM4113 dose-dependently blocked THC self-administration under a fixed-ratio 10 (FR10) schedule in squirrel monkeys. Mean±SEM of THC injections (4 μg/kg) (a, d) self-administered per 1 h session and overall rates of responding (b, e) are shown after i.m. pretreatment with rimonabant ((a, b) 0.03, 0.1, or 0.3 mg/kg; 60 min; n=3) or AM4113 ((d, e) 0.3, 1, or 3 mg/kg; 30 min; n=5) for 5 consecutive sessions (sessions 4–8) or vehicle (sessions 1–3 and 9–11). Rimonabant (c; 0.3 mg/kg) and AM4113 (f; 3 mg/kg) shifted THC dose–response curves down and to the right. Numbers of injections per session are presented as a function of injection dose of THC ((c, f) n=3). *P<0.05, different from the mean of three sessions with vehicle treatment (sessions 1–3). #P<0.05, different from vehicle treatment within each THC dose.