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. 2016 Mar 16;41(9):2309–2323. doi: 10.1038/npp.2016.33

Figure 6.

Figure 6

Repeated stress enhances the lateral nucleus (LAT) neuronal response to glutamate in adult rats. (a) Approximately 5–6 Hz firing rate of LAT neurons was induced by iontophoresis of glutamate (left). Repeated stress decreased the amount of iontophoretic glutamate needed to induce 5 Hz firing in adult rats but not in adolescent rats (right; *p<0.05, Holm–Sidak's multiple comparisons test after significance in a two-way analysis of variance (ANOVA). (b) In adult rats, repeated stress significantly enhanced the LAT neuronal firing response to iontophoretic glutamate (10–40 nA dose–response; *p<0.05, Holm–Sidak's multiple comparisons test after significance in a two-way repeated measures ANOVA). (c) In adolescent rats, there was no significant effect of repeated stress on glutamate-induced firing (10–40 nA dose–response; no significance in two-way repeated-measures ANOVA).