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. 1974 Mar;37(3):282–287. doi: 10.1136/jnnp.37.3.282

Relation of measles virus to encephalitogenic factor with reference to the aetiopathogenesis of multiple sclerosis

J R McDermott 1, E J Field 1,1, E A Caspary 1
PMCID: PMC494642  PMID: 4133588

Abstract

A combination of affinity chromatography with the macrophage electrophoretic migration (MEM) test has been used to study the antigenic similarities between encephalitogenic factor (EF) and measles virus. These have determinant(s) sufficiently closely related to account for the elevated level of circulating antibody to measles in multiple sclerosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brody J. A. Epidemiology of multiple sclerosis and a possible virus aetiology. Lancet. 1972 Jul 22;2(7769):173–176. doi: 10.1016/s0140-6736(72)91340-2. [DOI] [PubMed] [Google Scholar]
  2. CASPARY E. A., FIELD E. J. AN ENCEPHALITOGENIC PROTEIN OF HUMAN ORIGIN: SOME CHEMICAL AND BIOLOGICAL PROPERTIES. Ann N Y Acad Sci. 1965 Mar 31;122:182–198. doi: 10.1111/j.1749-6632.1965.tb20202.x. [DOI] [PubMed] [Google Scholar]
  3. Carnegie P. R., Caspary E. A., Dickinson J. P., Field E. J. The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization. A study of the kinetics. Clin Exp Immunol. 1973 May;14(1):37–45. [PMC free article] [PubMed] [Google Scholar]
  4. Caspary E. A., Chambers M. E., Field E. J. Antibodies to measles antigen, control antigen, and monkey kidney antigen. Studies in patients with multiple sclerosis and other neurological diseases and normal healthy individuals. Neurology. 1969 Nov;19(11):1038–1042. doi: 10.1212/wnl.19.11.1038. [DOI] [PubMed] [Google Scholar]
  5. Caspary E. A., Field E. J. Sensitization of blood lymphocytes to possible antigens in neurological disease. Eur Neurol. 1970;4(5):257–266. doi: 10.1159/000114027. [DOI] [PubMed] [Google Scholar]
  6. Caspary E. A., Field E. J. Specific lymphocyte sensitization in cancer: is there a common antigen in human malignant neoplasia? Br Med J. 1971 Jun 12;2(5762):613–617. doi: 10.1136/bmj.2.5762.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Coulson A. S., Chalmers D. G. Response of human blood lymphocytes to tuberculin PPD in tissue culture. Immunology. 1967 Apr;12(4):417–429. [PMC free article] [PubMed] [Google Scholar]
  8. FIELD E. J., CASPARY E. A., BALL E. J. Some biological properties of a highly active encephalitogenic factor isolated from human brain. Lancet. 1963 Jul 6;2(7297):11–13. doi: 10.1016/s0140-6736(63)92533-9. [DOI] [PubMed] [Google Scholar]
  9. Field E. J., Caspary E. A., Carnegie P. R. Lymphocyte sensitization to basic protein of brain in malignant neoplasia: experiments with serotonin and related compounds. Nature. 1971 Sep 24;233(5317):284–286. doi: 10.1038/233284a0. [DOI] [PubMed] [Google Scholar]
  10. Field E. J., Caspary E. A. Demonstration of sensitized lymphocytes in blood. J Clin Pathol. 1971 Mar;24(2):179–181. doi: 10.1136/jcp.24.2.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Field E. J., Caspary E. A. Lymphocyte sensitisation: an in-vitro test for cancer? Lancet. 1970 Dec 26;2(7687):1337–1341. doi: 10.1016/s0140-6736(70)92361-5. [DOI] [PubMed] [Google Scholar]
  12. Field E. J., Caspary E. A. Lymphocyte sensitization in advanced malignant disease: a study of serum lymphocyte depressive factor. Br J Cancer. 1972 Jun;26(3):164–173. doi: 10.1038/bjc.1972.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Field E. J., Caspary E. A., Madgwick H. Measles, multiple sclerosis, and encephalitogenic factor. Lancet. 1972 Aug 12;2(7772):337–337. doi: 10.1016/s0140-6736(72)92950-9. [DOI] [PubMed] [Google Scholar]
  14. Field E. J., Caspary E. A., Shenton B. K., Madgwick H. Lymphocyte sensitization after exposure to measles, and influenza. Possible relevance to pathogenesis of multiple sclerosis. J Neurol Sci. 1973 Jun;19(2):179–187. doi: 10.1016/0022-510x(73)90161-5. [DOI] [PubMed] [Google Scholar]
  15. Field E. J. Role of viral infection and autoimmunity in aetiology and pathogenesis of multiple sclerosis. Lancet. 1973 Feb 10;1(7798):295–297. doi: 10.1016/s0140-6736(73)91542-0. [DOI] [PubMed] [Google Scholar]
  16. Hughes D., Caspary E. A. Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques. Int Arch Allergy Appl Immunol. 1970;37(5):506–531. doi: 10.1159/000230240. [DOI] [PubMed] [Google Scholar]
  17. Inman J. K., Dintzis H. M. The derivatization of cross-linked polyacrylamide beads. Controlled introduction of functional groups for the preparation of special-purpose, biochemical adsorbents. Biochemistry. 1969 Oct;8(10):4074–4082. doi: 10.1021/bi00838a026. [DOI] [PubMed] [Google Scholar]
  18. Norrby E., Hammarskjöld B. Structural components of measles virus. Microbios. 1972 Jan;5(17):17–29. [PubMed] [Google Scholar]
  19. Salmi A. A., Panelius M., Norrby E. Multiple sclerosis and measles virus. Lancet. 1972 Nov 18;2(7786):1088–1089. doi: 10.1016/s0140-6736(72)92377-x. [DOI] [PubMed] [Google Scholar]
  20. Truffa-Bachi P., Wofsy L. Specific separation of cells on affinity columns. Proc Natl Acad Sci U S A. 1970 Jul;66(3):685–692. doi: 10.1073/pnas.66.3.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wigzell H., Andersson B. Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells. J Exp Med. 1969 Jan 1;129(1):23–36. doi: 10.1084/jem.129.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]

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