Abstract
In a necropsy study of brain water, sodium, and potassium concentrations is newborn infants, abnormalities were found in 10 out of 16 cases who were severely asphyxiated at birth. It is concluded that, although frank cerebral cortical necrosis is not often recognizable in perinatal deaths, early anoxic-ischaemic cerebral damage is frequent after intrapartum asphyxia. Diffuse cerebral swelling was associated with marked electrolyte disturbances and may be regarded as a feature of anoxic-ischaemic encephalopathy in asphyxiated newborn infants.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- APGAR V. A proposal for a new method of evaluation of the newborn infant. Curr Res Anesth Analg. 1953 Jul-Aug;32(4):260–267. [PubMed] [Google Scholar]
- De Souza S. W., Dobbing J. Cerebral edema in developing brain. I. Normal water and cation content in developing rat brain and postmortem changes. Exp Neurol. 1971 Sep;32(3):431–438. doi: 10.1016/0014-4886(71)90009-4. [DOI] [PubMed] [Google Scholar]
- Myers R. E., Beard R., Adamsons K. Brain swelling in the newborn rhesus monkey following prolonged partial asphyxia. Neurology. 1969 Oct;19(10):1012–1018. doi: 10.1212/wnl.19.10.1012. [DOI] [PubMed] [Google Scholar]
- NORMAN R. M., URICH H., MCMENEMEY W. H. Vascular mechanisms of birth injury. Brain. 1957 Mar;80(1):49–58. doi: 10.1093/brain/80.1.49. [DOI] [PubMed] [Google Scholar]
- Norris J. W., Pappius H. M. Cerebral water and electrolytes. Effect of asphyxia, hypoxia, and hypercapnia. Arch Neurol. 1970 Sep;23(3):248–258. doi: 10.1001/archneur.1970.00480270058008. [DOI] [PubMed] [Google Scholar]
- Pryse-Davies J., Beard R. W. A necropsy study of brain swelling in the newborn with special reference to cerebellar herniation. J Pathol. 1973 Jan;109(1):51–73. doi: 10.1002/path.1711090107. [DOI] [PubMed] [Google Scholar]
- SHAW C. M., ALVORD E. C., Jr, BERRY R. G. Swelling of the brain following ischemic infarction with arterial occlusion. Arch Neurol. 1959 Aug;1:161–177. doi: 10.1001/archneur.1959.03840020035006. [DOI] [PubMed] [Google Scholar]
- Selzer M. E., Myers R. E., Holstein S. B. Prolonged partial asphyxia: effects on fetal brain water and electrolytes. Neurology. 1972 Jul;22(7):732–737. doi: 10.1212/wnl.22.7.732. [DOI] [PubMed] [Google Scholar]