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. 1994 Jun;47(6):502–504. doi: 10.1136/jcp.47.6.502

Vitamin K dependent coagulation proteins in endemic hepatosplenomegaly in Egypt.

S A Omran 1, H M Amin 1, N E el-Bassiouni 1, F M Essawy 1, S M Toiema 1
PMCID: PMC494728  PMID: 8063929

Abstract

AIMS--To evaluate the role of bilharzial hepatic fibrosis--whether pure or combined with chronic hepatitis B virus infection--on the functional activity of vitamin K dependent coagulation proteins. METHODS--Coagulation screening using prothrombin time (PT), partial thromboplastin time (PTT), and thrombin time (TT) was carried out on 31 patients with endemic Egyptian hepatosplenomegaly and on 14 healthy controls. The functional activities of factors II, VII, IX and X and protein C were measured. Patients were classified as pure hepatosplenic schistosomiasis (n = 17) and schistosomiasis with concomitant chronic hepatitis B virus infection (n = 14). RESULTS--Prolongation of the PT and PTT were noticed in bilharzial patients compared with the controls. The increase in the TT remained within the upper range of normal. Factors II, VII, IX and X and protein C functional activities were significantly reduced in all groups studied. CONCLUSION--The decreased activity of vitamin K dependent coagulation factors might be partially offset by the reduced activity of circulating protein C which tends to establish a haemostatic balance at a lower level in endemic Egyptian hepatosplenomegaly. No significant difference could be shown between the pure and mixed cases. Schistosomal coagulopathy is therefore not necessarily aggravated by chronic hepatitis B virus infection.

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Selected References

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  1. Bassily S., Dunn M. A., Farid Z., Kilpatrick M. E., El-Masry N. A., Kamel I. A., El Alamy M., Murphy B. L. Chronic hepatitis B in patients with schistosomiasis mansoni. J Trop Med Hyg. 1983 Apr;86(2):67–71. [PubMed] [Google Scholar]
  2. Bassily S., Farid Z., Higashi G. I., Kamel I. A., El-Masry N. A., Watten R. H. Chronic hepatitis B antigenaemia in patients with hepatosplenic schistosomiasis. J Trop Med Hyg. 1979 Nov-Dec;82(11-12):248–251. [PubMed] [Google Scholar]
  3. Blanchard R. A., Furie B. C., Jorgensen M., Kruger S. F., Furie B. Acquired vitamin K-dependent carboxylation deficiency in liver disease. N Engl J Med. 1981 Jul 30;305(5):242–248. doi: 10.1056/NEJM198107303050502. [DOI] [PubMed] [Google Scholar]
  4. Corrigan J. J., Jeter M., Earnest D. L. Prothrombin antigen and coagulant activity in patients with liver disease. JAMA. 1982 Oct 8;248(14):1736–1739. [PubMed] [Google Scholar]
  5. Fujii M., Yasunaga K., Uchino H. Correlation analysis of relationships between vitamin-K-dependent clotting factors and effective hepatic blood flow, albumin and other liver function tests. Haemostasis. 1980;9(1):9–14. doi: 10.1159/000214335. [DOI] [PubMed] [Google Scholar]
  6. Hyams K. C., el Alamy M. A., Pazzaglia G., el Ghorab N. M., Sidhom O., Habib M., Dunn M. A. Risk of hepatitis B infection among Egyptians infected with Schistosoma mansoni. Am J Trop Med Hyg. 1986 Sep;35(5):1035–1039. doi: 10.4269/ajtmh.1986.35.1035. [DOI] [PubMed] [Google Scholar]
  7. Larouzé B., Dazza M. C., Gaudebout C., Habib M., Elamy M., Cline B. Absence of relationship between Schistosoma mansoni and hepatitis B virus infection in the Qalyub Governate, Egypt. Ann Trop Med Parasitol. 1987 Aug;81(4):373–375. doi: 10.1080/00034983.1987.11812134. [DOI] [PubMed] [Google Scholar]
  8. Lyra L. G., Rebouças G., Andrade Z. A. Hepatitis B surface antigen carrier state in hepatosplenic schistosomiasis. Gastroenterology. 1976 Oct;71(4):641–645. [PubMed] [Google Scholar]
  9. Manoukian N., Borges D. R. Prealbumin, prekallikrein and prothrombin in hepatosplenic schistosomiasis: increased turnover of the clotting proteins? Rev Inst Med Trop Sao Paulo. 1984 Sep-Oct;26(5):237–240. doi: 10.1590/s0036-46651984000500001. [DOI] [PubMed] [Google Scholar]
  10. Omran S. A., Hussein N. A., Mohamed A. A., el-Kaliouby A. H., Hussein A. T. Fibrinolysis and the bleeding tendency in patients with hepatosplenic schistosomiasis. J Clin Pathol. 1990 Jun;43(6):476–478. doi: 10.1136/jcp.43.6.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Orlando M., Casalbore P., Camagna A., Lauro R., Tardella L., Hassan H. J. Factor VII in liver cirrhosis. Haemostasis. 1982;11(2):73–78. doi: 10.1159/000214643. [DOI] [PubMed] [Google Scholar]
  12. van den Bosch C. A. The association of chronic hepatitis B infection with chronic Schistosomiasis mansoni in Kenya. East Afr Med J. 1987 Feb;64(2):95–101. [PubMed] [Google Scholar]

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