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. 1974 Jun;37(6):670–676. doi: 10.1136/jnnp.37.6.670

Contractile and electrical properties of human motor units in neuropathies and motor neurone disease

H S Milner-Brown 1,2, R B Stein 1,2,1, R G Lee 1,2
PMCID: PMC494739  PMID: 4844134

Abstract

The contractile and electrical properties of motor units in the first dorsal interosseous muscle of the hand have been studied in 26 patients with ulnar neuropathies and motor neurone disease (amyotrophic lateral sclerosis). Among patients with unilateral pressure or entrapment ulnar neuropathies, there was a tendency for the twitch tensions for single motor units to be smaller, while the surface EMG amplitudes were generally larger in the affected hands. Very large EMG amplitudes but normal size twitch tensions were observed among the motor neurone disease patients, indicating that, in general, motor units enlarged by sprouting are less efficient contractile units than units of normal physiological size.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buchthal F., Olsen P. Z. Electromyography and muscle biopsy in infantile spinal muscular atrophy. Brain. 1970;93(1):15–30. doi: 10.1093/brain/93.1.15. [DOI] [PubMed] [Google Scholar]
  2. EDWARDS R. G., LIPPOLD O. C. The relation between force and integrated electrical activity in fatigued muscle. J Physiol. 1956 Jun 28;132(3):677–681. doi: 10.1113/jphysiol.1956.sp005558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. ERMINIO F., BUCHTHAL F., ROSENFALCK P. Motor unit territory and muscle fiber concentration in paresis due to peripheral nerve injury and anterior horn cell involvement. Neurology. 1959 Oct;9:657–671. doi: 10.1212/wnl.9.10.657. [DOI] [PubMed] [Google Scholar]
  4. Mannard A., Stein R. B. Determination of the frequency response of isometric soleus muscle in the cat using random nerve stimulation. J Physiol. 1973 Mar;229(2):275–296. doi: 10.1113/jphysiol.1973.sp010138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. McComas A. J., Fawcett P. R., Campbell M. J., Sica R. E. Electrophysiological estimation of the number of motor units within a human muscle. J Neurol Neurosurg Psychiatry. 1971 Apr;34(2):121–131. doi: 10.1136/jnnp.34.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. McComas A. J., Sica R. E., Campbell M. J., Upton A. R. Functional compensation in partially denervated muscles. J Neurol Neurosurg Psychiatry. 1971 Aug;34(4):453–460. doi: 10.1136/jnnp.34.4.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Milner-Brown H. S., Stein R. B., Yemm R. The contractile properties of human motor units during voluntary isometric contractions. J Physiol. 1973 Jan;228(2):285–306. doi: 10.1113/jphysiol.1973.sp010087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Milner-Brown H. S., Stein R. B., Yemm R. The orderly recruitment of human motor units during voluntary isometric contractions. J Physiol. 1973 Apr;230(2):359–370. doi: 10.1113/jphysiol.1973.sp010192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Payan J. Anterior transposition of the ulnar nerve: an electrophysiological study. J Neurol Neurosurg Psychiatry. 1970 Apr;33(2):157–165. doi: 10.1136/jnnp.33.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sakuragawa N., Sato T., Tsubaki T. Scanning electron microscopic study of skeletal muscle. Normal, destrophic, and neurogenic atrophic muscle in mice and humans. Arch Neurol. 1973 Apr;28(4):247–251. doi: 10.1001/archneur.1973.00490220055008. [DOI] [PubMed] [Google Scholar]
  11. Sica R. E., McComas A. J. Fast and slow twitch units in a human muscle. J Neurol Neurosurg Psychiatry. 1971 Apr;34(2):113–120. doi: 10.1136/jnnp.34.2.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stein R. B., French A. S., Mannard A., Yemm R. New methods for analysing motor function in man and animals. Brain Res. 1972 May 12;40(1):187–192. doi: 10.1016/0006-8993(72)90126-6. [DOI] [PubMed] [Google Scholar]
  13. Stephens J. A., Taylor A. Fatigue of maintained voluntary muscle contraction in man. J Physiol. 1972 Jan;220(1):1–18. doi: 10.1113/jphysiol.1972.sp009691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. WOHLFART G. Collateral regeneration from residual motor nerve fibers in amyotrophic lateral sclerosis. Neurology. 1957 Feb;7(2):124–134. doi: 10.1212/wnl.7.2.124. [DOI] [PubMed] [Google Scholar]
  15. WOHLFART G. Collateral regeneration in partially denervated muscles. Neurology. 1958 Mar;8(3):175–180. doi: 10.1212/wnl.8.3.175. [DOI] [PubMed] [Google Scholar]

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