Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1974 Jun;37(6):685–690. doi: 10.1136/jnnp.37.6.685

Muscle blood flow in Duchenne type muscular dystrophy, limb-girdle dystrophy, polymyositis, and in normal controls 1

Olaf B Paulson 1,2,2, Andrew G Engel 1,2,3, Manuel R Gomez 1,2
PMCID: PMC494742  PMID: 4210685

Abstract

Muscle blood flow (MBF) was measured using the local 133Xenon injection method in patients with Duchenne type muscular dystrophy (six), limb-girdle dystrophy (four), polymyositis (seven), and in normal controls (11). Measurements were made at rest and during hyperaemia induced by ischaemic exercise and by histamine injection. Capillary diffusion capacity was measured with the 51Cr-EDTA method in three patients with Duchenne dystrophy and in six normal controls. Patients with Duchenne dystrophy had normal MBF during rest and during hyperaemia after exercise and significantly increased MBF after histamine injection. The capillary diffusion capacity was higher than normal, but not significantly. In limb-girdle dystrophy MBF was normal, while in polymyositis it was significantly decreased in all three circulatory states. The relevance of the findings to the proposed ischaemic aetiology of Duchenne dystrophy is considered.

Full text

PDF
685

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Demos J., Treumann F., Schroeder W. Anomalies de régulation de la micro-circulation musculaire chez les enfants atteints de dystrophie musculaire progressive par rapport a des enfants normaux du même age. Rev Fr Etud Clin Biol. 1968 May;13(5):467–483. [PubMed] [Google Scholar]
  2. Emery A. E., Schelling J. L. Limb blood flow in patients and carriers of Duchenne muscular dystrophy. Acta Genet Stat Med. 1965;15(3):337–344. doi: 10.1159/000151923. [DOI] [PubMed] [Google Scholar]
  3. González-Angulo A., Fraga A., Mintz G. Submicroscopic alterations in capillaries of skeletal muscles in polymyositis. Am J Med. 1968 Dec;45(6):873–879. doi: 10.1016/0002-9343(68)90185-x. [DOI] [PubMed] [Google Scholar]
  4. Hathaway P. W., Engel W. K., Zellweger H. Experimental myopathy after microarterial embolization; comparison with childhood x-linked pseudohypertrophic muscular dystrophy. Arch Neurol. 1970 Apr;22(4):365–378. doi: 10.1001/archneur.1970.00480220079011. [DOI] [PubMed] [Google Scholar]
  5. LASSEN N. A., LINDBJERG J., MUNCK O. MEASUREMENT OF BLOOD-FLOW THROUGH SKELETAL MUSCLE BY INTRAMUSCULAR INJECTION OF XENON-133. Lancet. 1964 Mar 28;1(7335):686–689. doi: 10.1016/s0140-6736(64)91518-1. [DOI] [PubMed] [Google Scholar]
  6. Lassen N. A., Trap-Jensen J. Theoretical considerations on measurement of capillary diffusion capacity in skeletal muscle by the local clearance method. Scand J Clin Lab Invest. 1968;21(2):108–115. doi: 10.3109/00365516809084272. [DOI] [PubMed] [Google Scholar]
  7. Lindbjerg I. F., Andersen A. M., Munck O., Jorgensen M. The fat content of leg muscles and its influence on the 133xenon clearance method of blood-flow measurement. Scand J Clin Lab Invest. 1966;18(5):525–534. doi: 10.3109/00365516609103915. [DOI] [PubMed] [Google Scholar]
  8. Lindbjerg I. F. Measurement of muscle blood-flow with 133-Xe after histamine injection as a diagnostic method in peripheral arterial disease. Scand J Clin Lab Invest. 1965;17(4):371–380. doi: 10.3109/00365516509077064. [DOI] [PubMed] [Google Scholar]
  9. Mendell J. R., Engel W. K., Derrer E. C. Duchenne muscular dystrophy: functional ischemia reproduces its characteristic lesions. Science. 1971 Jun 11;172(3988):1143–1145. doi: 10.1126/science.172.3988.1143. [DOI] [PubMed] [Google Scholar]
  10. Mendell J. R., Engel W. K., Derrer E. C. Increased plasma enzyme concentrations in rats with functional ischaemia of muscle provide a possible model of Duchenne muscular dystrophy. Nature. 1972 Oct 27;239(5374):522–524. doi: 10.1038/239522a0. [DOI] [PubMed] [Google Scholar]
  11. Norton W. L., Hurd E. R., Lewis D. C., Ziff M. Evidence of microvascular injury in scleroderma and systemic lupus erythematosus: quantitative study of the microvascular bed. J Lab Clin Med. 1968 Jun;71(6):919–933. [PubMed] [Google Scholar]
  12. Shafiq S. A., Milhorat A. T., Gorycki M. A. An electron-microscope study of muscle degeneration and vascular changes in polymyositis. J Pathol Bacteriol. 1967 Jul;94(1):139–147. doi: 10.1002/path.1700940118. [DOI] [PubMed] [Google Scholar]
  13. Trap-Jensen J., Korsgaard O., Lassen N. A. Capillary permeability to human skeletal muscle measured by local injection of 51Cr-EDTA and 133Xe. Scand J Clin Lab Invest. 1970 Jan;25(1):93–99. doi: 10.3109/00365517009046195. [DOI] [PubMed] [Google Scholar]
  14. Tönnesen K. H., Sejrsen P. Washout of 133Xenon after intramuscular injection and direct measurement of blood flow in skeletal muscle. Scand J Clin Lab Invest. 1970 Jan;25(1):71–81. doi: 10.3109/00365517009046193. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES