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. 1974 Jun;37(6):704–710. doi: 10.1136/jnnp.37.6.704

Use of cerebrospinal fluid drawn at pneumoencephalography in the study of monoamine metabolism in man

E Garelis 1,1, T L Sourkes 1,2
PMCID: PMC494750  PMID: 4210686

Abstract

Concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in CSF obtained after injection of air during pneumoencephalography (PEG) than in lumbar CSF, as drawn before the injection. There was a high correlation between levels in the `mixed' and lumbar samples of CSF in the case of each of the two acids. The concentration of lumbar HVA, but not that of 5-HIAA, was negatively correlated with CSF pressure. 5-HIAA levels were low in both samples of CSF in a group of epileptics, by comparison with controls. In two patients with Kufs disease and in one with Niemann-Pick disease, the concentration of HVA was very low in the lumbar sample. The application of a standardized PEG technique in the study of monoamine metabolism in man is suggested.

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Selected References

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