Table 2.
IL-6 | HIV-infected | HIV-uninfected | p-int HIV | ||
---|---|---|---|---|---|
beta | p-value | beta | p-value | ||
FEV1%predicted, post-BD | −0.24 | 0.01 | −0.20 | 0.01 | 0.6 |
FEV1/FVC ratio, post-BD | −0.13 | 0.2 | 0.02 | 0.8 | 0.3 |
DLCO %predicted | −0.35 | <0.001 | −0.37 | <0.001 | 0.7 |
OR | p-value | OR | p-value | ||
FEV1/FVC < 70%, post-BD | 1.04 | 0.09 | 1.0 | 0.9 | 0.2 |
Positive BD response | 1.06 | 0.051 | 1.0 | 0.9 | 0.1 |
IL-8 | |||||
beta | p-value | beta | p-value | ||
FEV1%predicted, post-BD | −0.17 | 0.06 | 0.05 | 0.6 | 0.08 |
FEV1/FVC ratio, post-BD | −0.16 | 0.08 | 0.04 | 0.7 | 0.1 |
DLCO %predicted | −0.12 | 0.2 | 0.0 | n/a | 0.3 |
OR | p-value | OR | p-value | ||
FEV1/FVC < 70%, post-BD | 2.4 | 0.1 | 1.0 | 0.9 | 0.3 |
Positive BD response | 1.8 | 0.4 | 1.3 | 0.8 | 0.8 |
TNF-α | |||||
beta | p-value | beta | p-value | ||
FEV1%predicted, post-BD | −0.18 | 0.07 | −0.05 | 0.5 | 0.3 |
FEV1/FVC ratio, post-BD | −0.04 | 0.7 | 0.10 | 0.2 | 0.3 |
DLCO %predicted | −0.38 | <0.001 | −0.32 | <0.001 | 0.6 |
OR | p-value | OR | p-value | ||
FEV1/FVC < 70%, post-BD | 1.01 | 0.2 | 1.0 | 0.9 | 0.3 |
Positive BD response | 1.02 | 0.03 | 1.0 | 0.6 | 0.06 |
LPS | |||||
beta | p-value | beta | p-value | ||
FEV1%predicted, post-BD | 0.07 | 0.5 | −0.06 | 0.5 | 0.5 |
FEV1/FVC ratio, post-BD | 0.07 | 0.5 | −0.01 | 0.9 | 0.7 |
DLCO %predicted | −0.19 | 0.03 | −0.24 | 0.004 | 0.9 |
OR | p-value | OR | p-value | ||
FEV1/FVC < 70%, post-BD | 0.7 | 0.4 | 1.0 | 0.9 | 0.7 |
Positive BD response | 1.2 | 0.7 | 1.0 | 0.9 | 0.8 |
sCD14 | |||||
beta | p-value | beta | p-value | ||
FEV1%predicted, post-BD | −0.08 | 0.5 | −0.11 | 0.2 | 0.7 |
FEV1/FVC ratio, post-BD | −0.12 | 0.2 | 0.04 | 0.6 | 0.2 |
DLCO %predicted | −0.06 | 0.5 | −0.05 | 0.5 | 0.9 |
OR | p-value | OR | p-value | ||
FEV1/FVC < 70%, post-BD | 2.4 | 0.4 | 0.5 | 0.5 | 0.2 |
Positive BD response | 0.2 | 0.09 | 0.6 | 0.7 | 0.5 |
sCD163 | |||||
beta | p-value | beta | p-value | ||
FEV1%predicted, post-BD | −0.13 | 0.2 | −0.12 | 0.2 | 0.8 |
FEV1/FVC ratio, post-BD | −0.23 | 0.01 | −0.07 | 0.4 | 0.2 |
DLCO %predicted | −0.18 | 0.04 | −0.15 | 0.07 | 0.6 |
OR | p-value | OR | p-value | ||
FEV1/FVC < 70%, post-BD | 3.8 | 0.06 | 1.2 | 0.7 | 0.2 |
Positive BD response | 4.9 | 0.04 | 0.6 | 0.5 | 0.05 |
IL-2sRα | |||||
beta | p-value | beta | p-value | ||
FEV1%predicted, post-BD | −0.12 | 0.2 | −0.20 | 0.02 | 0.4 |
FEV1/FVC ratio, post-BD | −0.04 | 0.6 | −0.07 | 0.4 | 0.8 |
DLCO %predicted | −0.25 | 0.005 | −0.24 | 0.004 | 0.9 |
OR | p-value | OR | p-value | ||
FEV1/FVC < 70%, post-BD | 1.4 | 0.6 | 1.6 | 0.5 | 0.9 |
Positive BD response | 1.4 | 0.6 | 1.4 | 0.7 | 0.9 |
ET-1 | |||||
beta | p-value | beta | p-value | ||
FEV1%predicted, post-BD | −0.36 | <0.001 | −0.04 | 0.6 | 0.003 |
FEV1/FVC ratio, post-BD | −0.14 | 0.1 | −0.11 | 0.2 | 0.8 |
DLCO %predicted | −0.32 | <0.001 | −0.07 | 0.4 | 0.02 |
OR | p-value | OR | p-value | ||
FEV1/FVC < 70%, post-BD | 4.8 | 0.04 | 1.9 | 0.3 | 0.3 |
Positive BD response | 7.6 | 0.03 | 4.9 | 0.053 | 0.8 |
BD: bronchodilator, DLCO: diffusing capacity for carbon monoxide, ET-1: endothelin-1, FEV1: forced expiratory volume in one second, FVC: forced vital capacity, IL: interleukin, IL-2sRα: IL-2 soluble receptor alpha, LPS: lipopolysaccharide, TNF-α: tumor necrosis factor alpha
p-int HIV: p-value for interaction of biomarker and HIV status with pulmonary function outcome