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. 1974 Sep;37(9):1036–1046.

Motor neurone disease: the nature of the pathogenic mechanism

D M A Mann 1, P O Yates 1
PMCID: PMC494835

Abstract

Evidence is presented which indicates that the initial site of action of the pathogen of motor neurone disease (MND) is the nucleus, and its prime effect is to cause the progressive inhibition of DNA directed mRNA synthesis by the slow condensation of chromatin from a metabolically active diffuse form to an inactive form. The other pathological changes observed follow as part of a nonspecific cell atrophy which leads eventually to dysfunction, death, and disappearance of cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FRIEDE R. L., DEJONG R. N. NEURONAL ENZYMATIC FAILURE IN CREUTZFELDT-JAKOB DISEASE; A FAMILIAL STUDY. Arch Neurol. 1964 Feb;10:181–195. doi: 10.1001/archneur.1964.00460140067009. [DOI] [PubMed] [Google Scholar]
  2. HSU T. C. Differential rate in RNA synthesis between euchromatin and heterochromatin. Exp Cell Res. 1962 Aug;27:332–334. doi: 10.1016/0014-4827(62)90238-0. [DOI] [PubMed] [Google Scholar]
  3. KURLAND L. T., MULDER D. W. Epidemiologic investigations of amyotrophic lateral sclerosis. 2. Familial aggregations indicative of dominant inheritance. I. Neurology. 1955 Mar;5(3):182–196. doi: 10.1212/wnl.5.3.182. [DOI] [PubMed] [Google Scholar]
  4. KURLAND L. T., MULDER D. W. Epidemiologic investigations of amyotrophic lateral sclerosis. I. Preliminary report on geographic distribution, with special reference to the Mariana Islands, including clinical and pathologic observations. Neurology. 1954 May;4(5):355–378. doi: 10.1212/wnl.4.5.355. [DOI] [PubMed] [Google Scholar]
  5. Koenig H., Jacobson S. Cytochemical and ultrastructural effects of actinomycin D in cat spinal cord. J Neuropathol Exp Neurol. 1967 Jan;26(1):148–149. [PubMed] [Google Scholar]
  6. Koenig H. Neurobiological action of some pyrimidine analogs. Int Rev Neurobiol. 1967;10:199–230. doi: 10.1016/s0074-7742(08)60154-3. [DOI] [PubMed] [Google Scholar]
  7. LITTAU V. C., ALLFREY V. G., FRENSTER J. H., MIRSKY A. E. ACTIVE AND INACTIVE REGIONS OF NUCLEAR CHROMATIN AS REVEALED BY ELECTRON MICROSCOPE AUTORADIOGRAPHY. Proc Natl Acad Sci U S A. 1964 Jul;52:93–100. doi: 10.1073/pnas.52.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MENDELSOHN M. L. The two-wavelength method of microspectrophotometry. II. A set of tables to facilitate the calculations. J Biophys Biochem Cytol. 1958 Jul 25;4(4):415–424. doi: 10.1083/jcb.4.4.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. ORNSTEIN L. The distributional error in microspectrophotometry. Lab Invest. 1952;1(2):250–265. [PubMed] [Google Scholar]
  10. PATAU K. Absorption microphotometry of irregular-shaped objects. Chromosoma. 1952;5(4):341–362. doi: 10.1007/BF01271492. [DOI] [PubMed] [Google Scholar]
  11. Reich E., Goldberg I. H. Actinomycin and nucleic acid function. Prog Nucleic Acid Res Mol Biol. 1964;3:183–234. doi: 10.1016/s0079-6603(08)60742-4. [DOI] [PubMed] [Google Scholar]
  12. Shea J. R., Jr A method for in situ cytophotometric estimation of absolute amount of ribonucleic acid using azure B1. J Histochem Cytochem. 1970 Feb;18(2):143–152. doi: 10.1177/18.2.143. [DOI] [PubMed] [Google Scholar]
  13. ZILBER L. A., BAJDAKOVA Z. L., GARDASJAN A. N., KONOVALOV N. V., BUNINA T. L., BARABADZE E. M. STUDY OF THE ETIOLOGY OF AMYOTROPHIC LATERAL SCLEROSIS. Bull World Health Organ. 1963;29:449–456. [PMC free article] [PubMed] [Google Scholar]

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