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. 1974 Oct;37(10):1093–1098. doi: 10.1136/jnnp.37.10.1093

Intracranial volume–pressure relationships during experimental brain compression in primates

1. Pressure responses to changes in ventricular volume

Peter Leech 1, J Douglas Miller 1
PMCID: PMC494850  PMID: 4443803

Abstract

Intermittent additions of 0·05 ml saline were made into the lateral ventricle of anaesthetized, ventilated baboons at regular intervals during continuous inflation of a supratentorial extradural balloon. Close correlation was observed both between the increase in ventricular fluid pressure (VFP) immediately after the injection and the volume in the balloon (P < 0·001); and between the increase in ventricular pressure and the pressure immediately before the injection (P < 0·001). This change in ventricular fluid pressure, which is termed the volume–pressure response (VPR), helps to delineate the stage reached on the intracranial volume–pressure curve, and is therefore a measure of the capacity of the intracranial contents to compensate for the volume changes produced by an expanding intracranial lesion. The VPR is currently being used in patients and the clinical implications of confirming its validity experimentally are therefore discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Johnston I. H., Johnston J. A., Jennett B. Intracranial-pressure changes following head injury. Lancet. 1970 Aug 29;2(7670):433–436. doi: 10.1016/s0140-6736(70)90054-1. [DOI] [PubMed] [Google Scholar]
  2. Johnston I. H., Rowan J. O., Harper A. M., Jennett W. B. Raised intracranial pressure and cerebral blood flow. 2. Supratentorial and infratentorial mass lesions in primates. J Neurol Neurosurg Psychiatry. 1973 Apr;36(2):161–170. doi: 10.1136/jnnp.36.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. LANGFITT T. W., WEINSTEIN J. D., KASSELL N. F. CEREBRAL VASOMOTOR PARALYSIS PRODUCED BY INTRACRANIAL HYPERTENSION. Neurology. 1965 Jul;15:622–641. doi: 10.1212/wnl.15.7.622. [DOI] [PubMed] [Google Scholar]
  4. Langfitt T. W. Increased intracranial pressure. Clin Neurosurg. 1969;16:436–471. doi: 10.1093/neurosurgery/16.cn_suppl_1.436. [DOI] [PubMed] [Google Scholar]
  5. Lundberg N., Troupp H., Lorin H. Continuous recording of the ventricular-fluid pressure in patients with severe acute traumatic brain injury. A preliminary report. J Neurosurg. 1965 Jun;22(6):581–590. doi: 10.3171/jns.1965.22.6.0581. [DOI] [PubMed] [Google Scholar]
  6. Löfgren J., von Essen C., Zwetnow N. N. The pressure-volume curve of the cerebrospinal fluid space in dogs. Acta Neurol Scand. 1973;49(5):557–574. doi: 10.1111/j.1600-0404.1973.tb01330.x. [DOI] [PubMed] [Google Scholar]
  7. Miller J. D., Garibi J., Pickard J. D. Induced changes of cerebrospinal fluid volume. Effects during continuous monitoring of ventricular fluid pressure. Arch Neurol. 1973 Apr;28(4):265–269. doi: 10.1001/archneur.1973.00490220073011. [DOI] [PubMed] [Google Scholar]
  8. Miller J. D., Pickard J. D. Intracranial volume pressure studies in patients with head injury. Injury. 1974 Feb;5(3):265–268. doi: 10.1016/s0020-1383(74)80021-5. [DOI] [PubMed] [Google Scholar]
  9. Miller J. D., Stanek A. E., Langfitt T. W. Cerebral blood flow regulation during experimental brain compression. J Neurosurg. 1973 Aug;39(2):186–196. doi: 10.3171/jns.1973.39.2.0186. [DOI] [PubMed] [Google Scholar]
  10. Richardson A., Hide T. A., Eversden I. D. Long-term continuous intracranial-pressure monitoring by means of a modified subdural pressure transducer. Lancet. 1970 Oct 3;2(7675):687–690. doi: 10.1016/s0140-6736(70)91960-4. [DOI] [PubMed] [Google Scholar]
  11. Rowan J. O., Harper A. M., Miller J. D., Tedeschi G. M., Jennett W. B. Relationship between volume flow and velocity in the cerebral circulation. J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):733–738. doi: 10.1136/jnnp.33.6.733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SHULMAN K. SMALL ARTERY AND VEIN PRESSURES IN THE SUBARACHNOID SPACE OF THE DOG. J Surg Res. 1965 Feb;5:56–61. doi: 10.1016/s0022-4804(65)80067-1. [DOI] [PubMed] [Google Scholar]
  13. Severinghaus J. W. Blood gas calculator. J Appl Physiol. 1966 May;21(3):1108–1116. doi: 10.1152/jappl.1966.21.3.1108. [DOI] [PubMed] [Google Scholar]

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