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. 1974 Nov;37(11):1214–1224. doi: 10.1136/jnnp.37.11.1214

Diagnostic difficulties encountered in the myasthenic syndrome sometimes associated with carcinoma

J Colin Brown 1,2,1, Richard J Johns 1,2
PMCID: PMC494885  PMID: 4376163

Abstract

Six patients with the physiological features of the myasthenic syndrome associated with carcinoma are presented. The clinical features encountered in this group, including age, mode of onset, and duration of symptom indicate that it may escape detection owing to its resemblance to other neuromuscular disorders. Conventional concentric needle electromyography may lead to the disorder being confused with a myopathy. The association with carcinoma is by no means constant. Clinical and physiological improvement with guanidine is described in each case.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOTELHO S. Y., DEATERLY C. F., AUSTIN S., COMROE J. H., Jr Evaluation of the electromyogram of patients with myasthenia gravis. AMA Arch Neurol Psychiatry. 1952 Apr;67(4):441–450. doi: 10.1001/archneurpsyc.1952.02320160025003. [DOI] [PubMed] [Google Scholar]
  2. Bergman R. A., Johns R. J. Ultrastructural alterations in muscle from patients with myasthenia gravis and Eaton-Lumbert syndrome. Ann N Y Acad Sci. 1971 Sep 15;183:88–122. doi: 10.1111/j.1749-6632.1971.tb30744.x. [DOI] [PubMed] [Google Scholar]
  3. Brown J. C., Johns R. J. Clinical and physiological studies of the effect of guanidine of patients with myasthenia gravis. Johns Hopkins Med J. 1969 Jan;124(1):1–8. [PubMed] [Google Scholar]
  4. GROB D., HARVEY A. M., JOHNS R. J. Studies in neuromuscular function. I. Introduction and methods. Bull Johns Hopkins Hosp. 1956 Sep;99(3):115–124. [PubMed] [Google Scholar]
  5. HENSON R. A., RUSSELL D. S., WILKINSON M. Carcinomatous neuropathy and myopathy a clinical and pathological study. Brain. 1954;77(1):82–121. doi: 10.1093/brain/77.1.82. [DOI] [PubMed] [Google Scholar]
  6. Hofmann W. W., Kundin J. E., Farrell D. F. The pseudomyasthenic syndrome of Eaton and Lambert: an electrophysiological study. Electroencephalogr Clin Neurophysiol. 1967 Sep;23(3):214–224. doi: 10.1016/0013-4694(67)90118-6. [DOI] [PubMed] [Google Scholar]
  7. Lambert E. H. Defects of neuromuscular transmission in syndromes other than myasthenia gravis. Ann N Y Acad Sci. 1966 Jan 26;135(1):367–384. doi: 10.1111/j.1749-6632.1966.tb45484.x. [DOI] [PubMed] [Google Scholar]
  8. McQuillen M. P., Johns R. J. The nature of the defect in the Eaton-Lambert syndrome. Neurology. 1967 Jun;17(6):527–536. doi: 10.1212/wnl.17.6.527. [DOI] [PubMed] [Google Scholar]
  9. OTSUKA M., ENDO M. The effect of guanidine on neuromuscular transmission. J Pharmacol Exp Ther. 1960 Mar;128:273–282. [PubMed] [Google Scholar]
  10. Oh S. J. The Eaton-Lambert syndrome. Report of a case. Arch Neurol. 1972 Jul;27(1):91–94. doi: 10.1001/archneur.1972.00490130093014. [DOI] [PubMed] [Google Scholar]
  11. Satoyoshi E., Kowa H., Fukunaga N. Subacute cerebellar degeneration and Eaton-Lambert syndrome with bronchogenic carcinoma. A case report. Neurology. 1973 Jul;23(7):764–768. doi: 10.1212/wnl.23.7.764. [DOI] [PubMed] [Google Scholar]
  12. Stanton J. B., Strong J. A. Myopathy remitting in pregnancy and responding to high-dosage oestrogen and progestogen therapy. Lancet. 1967 Aug 5;2(7510):275–277. doi: 10.1016/s0140-6736(67)90112-2. [DOI] [PubMed] [Google Scholar]
  13. Takamori M., Gutmann L. Intermittent defect of acetylcholine release in myasthenia gravis. Neurology. 1971 Jan;21(1):47–54. doi: 10.1212/wnl.21.1.47. [DOI] [PubMed] [Google Scholar]

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