Abstract
An unusual case of cerebral toxoplasmosis in an HIV negative 11 year old child is reported. Central nervous system disease was assessed immunohistochemically in a brain biopsy specimen with TgP8--a specific monoclonal antibody against Toxoplasma gondii antigens--thus confirming IgG and IgM serology, technetium scan findings, and clinical data. In addition, an active parasitaemia was confirmed by DNA in situ hybridisation assay in white cells using an ABGTg4 probe. The child recovered after specific T gondii treatment. Follow up six months later showed that he was immunodeficient.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Angel S., Maero E., Blanco J. C., Pzsenny V., Zala C., Gonzalez R., Perelmulter H., Garberi J. C. Early diagnosis of toxoplasmic encephalitis in AIDS patients by dot blot hybridization analysis. J Clin Microbiol. 1992 Dec;30(12):3286–3287. doi: 10.1128/jcm.30.12.3286-3287.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blanco J. C., Angel S. O., Maero E., Pszenny V., Serpente P., Garberi J. C. Cloning of repetitive DNA sequences from Toxoplasma gondii and their usefulness for parasite detection. Am J Trop Med Hyg. 1992 Mar;46(3):350–357. doi: 10.4269/ajtmh.1992.46.350. [DOI] [PubMed] [Google Scholar]
- FELDMAN H. A., MILLER L. T. Serological study of toxoplasmosis prevalence. Am J Hyg. 1956 Nov;64(3):320–335. doi: 10.1093/oxfordjournals.aje.a119845. [DOI] [PubMed] [Google Scholar]
- Ho-Yen D. O., Joss A. W., Balfour A. H., Smyth E. T., Baird D., Chatterton J. M. Use of the polymerase chain reaction to detect Toxoplasma gondii in human blood samples. J Clin Pathol. 1992 Oct;45(10):910–913. doi: 10.1136/jcp.45.10.910. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Luft B. J., Remington J. S. AIDS commentary. Toxoplasmic encephalitis. J Infect Dis. 1988 Jan;157(1):1–6. doi: 10.1093/infdis/157.1.1. [DOI] [PubMed] [Google Scholar]
- Porter S. B., Sande M. A. Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome. N Engl J Med. 1992 Dec 3;327(23):1643–1648. doi: 10.1056/NEJM199212033272306. [DOI] [PubMed] [Google Scholar]