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. 1991 Dec;44(12):1003–1006. doi: 10.1136/jcp.44.12.1003

Lung mast cells in plexogenic pulmonary arteriopathy.

D Heath 1, M Yacoub 1
PMCID: PMC494968  PMID: 1791199

Abstract

The numbers of mast cells/mm2 of lung parenchyma were counted in four controls, 15 cases of primary plexogenic pulmonary arteriopathy (PPA), and 17 cases in which the arteriopathy was secondary to congenital heart disease, to determine if increased numbers occur in PPA and with what stage of disease they might be associated. Considerable accumulations of lung mast cells may occur in this disease, but these are not closely related to any particular histological stage in the development of the arteriopathy. It is postulated that while mast cells could conceivably exert a vasodilatory effect on constricted small pulmonary arteries, it seems more likely that they are part of the parenchymal changes that commonly develop in this disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aviado D. M., Samanék M., Folle L. E. Cardiopulmonary effects of tobacco and related substances. I. The release of histamine during inhalation of cigarette smoke and anoxemia in the heart-lung and intact dog preparation. Arch Environ Health. 1966 Jun;12(6):705–711. doi: 10.1080/00039896.1966.10664468. [DOI] [PubMed] [Google Scholar]
  2. Bergofsky E. H. Mechanisms underlying vasomotor regulation of regional pulmonary blood flow in normal and disease states. Am J Med. 1974 Sep;57(3):378–394. doi: 10.1016/0002-9343(74)90133-8. [DOI] [PubMed] [Google Scholar]
  3. Caslin A. W., Heath D., Madden B., Yacoub M., Gosney J. R., Smith P. The histopathology of 36 cases of plexogenic pulmonary arteriopathy. Histopathology. 1990 Jan;16(1):9–19. doi: 10.1111/j.1365-2559.1990.tb01054.x. [DOI] [PubMed] [Google Scholar]
  4. Crow J., More L., Howe S. The mast cells of the human uterus. APMIS. 1988 Oct;96(10):921–926. doi: 10.1111/j.1699-0463.1988.tb00963.x. [DOI] [PubMed] [Google Scholar]
  5. HEATH D., EDWARDS J. E. Histological changes in the lung in diseases associated with pulmonary venous hypertension. Br J Dis Chest. 1959 Jan;53(1):8–18. doi: 10.1016/s0007-0971(59)80105-4. [DOI] [PubMed] [Google Scholar]
  6. HEATH I. D. Staining of sulphated mucopolysaccharides. Nature. 1961 Sep 30;191:1370–1371. doi: 10.1038/1911370a0. [DOI] [PubMed] [Google Scholar]
  7. Haas F., Bergofsky E. H. Role of the mast cell in the pulmonary pressor response to hypoxia. J Clin Invest. 1972 Dec;51(12):3154–3162. doi: 10.1172/JCI107142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hauge A. Role of histamine in hypoxic pulmonary hypertension in the rat. I. Blockade or potentiation of endogenous amines, kinins, and ATP. Circ Res. 1968 Mar;22(3):371–383. doi: 10.1161/01.res.22.3.371. [DOI] [PubMed] [Google Scholar]
  9. Heath D., Trueman T., Sukonthamarn P. Pulmonary mast cells in mitral stenosis. Cardiovasc Res. 1969 Oct;3(4):467–471. doi: 10.1093/cvr/3.4.467. [DOI] [PubMed] [Google Scholar]
  10. Heath D., Yacoub M., Gosney J. R., Madden B., Caslin A. W., Smith P. Pulmonary endocrine cells in hypertensive pulmonary vascular disease. Histopathology. 1990 Jan;16(1):21–28. doi: 10.1111/j.1365-2559.1990.tb01055.x. [DOI] [PubMed] [Google Scholar]
  11. Kay J. M., Gillund T. D., Heath D. Mast cells in the lungs of rats fed on Crotalaria spectabilis seeds. Am J Pathol. 1967 Dec;51(6):1031–1044. [PMC free article] [PubMed] [Google Scholar]
  12. Kay J. M., Waymire J. C., Grover R. F. Lung mast cell hyperplasia and pulmonary histamine-forming capacity in hypoxic rats. Am J Physiol. 1974 Jan;226(1):178–184. doi: 10.1152/ajplegacy.1974.226.1.178. [DOI] [PubMed] [Google Scholar]
  13. Mungall I. P. Hypoxia and lung mast cells: influence of disodium cromoglycate. Thorax. 1976 Feb;31(1):94–100. doi: 10.1136/thx.31.1.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. TAKEOKA O., ANGEVINE D. M., LALICH J. J. Stimulation of mast cells in rats fed various chemicals. Am J Pathol. 1962 May;40:545–554. [PMC free article] [PubMed] [Google Scholar]
  15. Williams A., Heath D., Harris P., Williams D., Smith P. Pulmonary mast cells in cattle and ilamas at high altitude. J Pathol. 1981 May;134(1):1–6. doi: 10.1002/path.1711340102. [DOI] [PubMed] [Google Scholar]
  16. Wingren U., Enerbäck L. Mucosal mast cells of the rat intestine: a re-evaluation of fixation and staining properties, with special reference to protein blocking and solubility of the granular glycosaminoglycan. Histochem J. 1983 Jun;15(6):571–582. doi: 10.1007/BF01954148. [DOI] [PubMed] [Google Scholar]

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