Abstract
A patient with atypical Ph negative chronic myeloid leukaemia presented with the sudden onset of profound deafness. He survived only eight months. Detailed histological investigation performed at necropsy showed loss of ganglion cells and afferent nerve fibres in the cochlea and vestibule associated with extensive fibrosis and new bone formation in the labyrinthine spaces. Both leucophoresis and high dose chemotherapy capable of rapid cytoreduction are recommended in patients with chronic myeloid leukaemia with profound hearing loss, as conventional chemotherapy is rarely followed by recovery.
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- Onwukeme K. E., Sagoe A. S., Bhatia P. L. Sensori-neural hearing impairment in chronic granulocytic leukaemia. Trop Geogr Med. 1987 Jan;39(1):24–27. [PubMed] [Google Scholar]
- Paparella M. M., Berlinger N. T., Oda M., el-Fiky F. Otological manifestations of leukemia. Laryngoscope. 1973 Sep;83(9):1510–1526. doi: 10.1288/00005537-197309000-00010. [DOI] [PubMed] [Google Scholar]
- Preston F. E., Sokol R. J., Lilleyman J. S., Winfield D. A., Blackburn E. K. Cellular hyperviscosity as a cause of neurological symptoms in leukaemia. Br Med J. 1978 Feb 25;1(6111):476–478. doi: 10.1136/bmj.1.6111.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams C. K., Ogan O. Chronic myeloid leukemia associated with impairment of hearing. Br Med J (Clin Res Ed) 1985 Jun 8;290(6483):1705–1705. doi: 10.1136/bmj.290.6483.1705. [DOI] [PMC free article] [PubMed] [Google Scholar]