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. 1992 Oct;45(10):894–897. doi: 10.1136/jcp.45.10.894

Amyloid in prostatic corpora amylacea.

P A Cross 1, C J Bartley 1, J McClure 1
PMCID: PMC495061  PMID: 1385482

Abstract

AIM: To determine the presence and nature of amyloid in prostatic corpora amylacea using immunohistological studies. METHODS: Prostatic tissue from 18 transurethral and two open resection specimens was studied. Paraffin wax embedded tissue sections were stained with haematoxylin and eosin and the alkaline Congo red method with and without previous treatment with potassium permanganate. Sections were also stained with antibodies to amyloid A, beta 2 microglobulin, lambda and kappa light chains, prealbumin IgA, G, M, S100 protein, prostatic specific antigen, amyloid P component and CAM 5.2 (control and blocking studies were performed). RESULTS: The prostatic corpora amylacea universally showed the presence of amyloid. In all instances this contained beta 2 microglobulin. CONCLUSION: Prostatic corpora amylacea represents a localised amyloidosis of beta 2 microglobulin origin that is unrelated to chronic renal failure and haemodialysis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Achtstätter T., Moll R., Moore B., Franke W. W. Cytokeratin polypeptide patterns of different epithelia of the human male urogenital tract: immunofluorescence and gel electrophoretic studies. J Histochem Cytochem. 1985 May;33(5):415–426. doi: 10.1177/33.5.2580881. [DOI] [PubMed] [Google Scholar]
  2. Bardin T., Kuntz D. The arthropathy of chronic haemodialysis. Clin Exp Rheumatol. 1987 Oct-Dec;5(4):379–386. [PubMed] [Google Scholar]
  3. Battaglia S., Barbolini G., Botticelli A. R., Trentini G. P. Apoptotic amyloid: a study on prostatic amyloidosis with particular reference to corpora amylacea. Appl Pathol. 1985;3(1-2):105–114. [PubMed] [Google Scholar]
  4. Connors L. H., Shirahama T., Skinner M., Fenves A., Cohen A. S. In vitro formation of amyloid fibrils from intact beta 2-microglobulin. Biochem Biophys Res Commun. 1985 Sep 30;131(3):1063–1068. doi: 10.1016/0006-291x(85)90198-6. [DOI] [PubMed] [Google Scholar]
  5. Gejyo F., Odani S., Yamada T., Honma N., Saito H., Suzuki Y., Nakagawa Y., Kobayashi H., Maruyama Y., Hirasawa Y. Beta 2-microglobulin: a new form of amyloid protein associated with chronic hemodialysis. Kidney Int. 1986 Sep;30(3):385–390. doi: 10.1038/ki.1986.196. [DOI] [PubMed] [Google Scholar]
  6. Lupovitch A. The prostate and amyloidosis. J Urol. 1972 Aug;108(2):301–302. doi: 10.1016/s0022-5347(17)60719-5. [DOI] [PubMed] [Google Scholar]
  7. Marx A. J., Moskal J. F., Gueft B. Prostatic corpora amylacea. A study with the electron microscope and electron probe. Arch Pathol. 1965 Nov;80(5):487–494. [PubMed] [Google Scholar]
  8. Messner R. P. Beta 2-microglobulin: an old molecule assumes a new look. J Lab Clin Med. 1984 Aug;104(2):141–145. [PubMed] [Google Scholar]
  9. Nelson G., Culberson D. E., Gardner W. A., Jr Intraprostatic spermatozoa. Hum Pathol. 1988 May;19(5):541–544. doi: 10.1016/s0046-8177(88)80201-6. [DOI] [PubMed] [Google Scholar]
  10. Noël L. H., Zingraff J., Bardin T., Atienza C., Kuntz D., Drüeke T. Tissue distribution of dialysis amyloidosis. Clin Nephrol. 1987 Apr;27(4):175–178. [PubMed] [Google Scholar]
  11. Ogawa H., Saito A., Hirabayashi N., Hara K. Amyloid deposition in systemic organs in long-term hemodialysis patients. Clin Nephrol. 1987 Oct;28(4):199–204. [PubMed] [Google Scholar]
  12. PRATHER G. C., SKINNER D. Prostatic corpora amylacea. J Urol. 1956 Jul;76(1):107–114. doi: 10.1016/S0022-5347(17)66667-9. [DOI] [PubMed] [Google Scholar]
  13. SEAMAN A. R. Cytochemical observations on the corpora amylacea of the human prostate gland. J Urol. 1956 Jul;76(1):99–106. doi: 10.1016/S0022-5347(17)66666-7. [DOI] [PubMed] [Google Scholar]
  14. Schrodt G. R., Murray M. The keratin structure of corpora amylacea. Arch Pathol. 1966 Dec;82(6):518–525. [PubMed] [Google Scholar]
  15. Shirahama T., Skinner M., Cohen A. S., Gejyo F., Arakawa M., Suzuki M., Hirasawa Y. Histochemical and immunohistochemical characterization of amyloid associated with chronic hemodialysis as beta 2-microglobulin. Lab Invest. 1985 Dec;53(6):705–709. [PubMed] [Google Scholar]
  16. Vincent C., Revillard J. P., Galland M., Traeger J. Serum beta2-microglobulin in hemodialyzed patients. Nephron. 1978;21(5):260–268. doi: 10.1159/000181402. [DOI] [PubMed] [Google Scholar]
  17. Wilson S. K., Buchanan R. D., Stone W. J., Rhamy R. K. Amyloid deposition in the prostate. J Urol. 1973 Sep;110(3):322–323. doi: 10.1016/s0022-5347(17)60202-7. [DOI] [PubMed] [Google Scholar]
  18. Wright J. R., Calkins E., Humphrey R. L. Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease. Lab Invest. 1977 Mar;36(3):274–281. [PubMed] [Google Scholar]

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