Abstract
Most patients with gonadoblastoma have dysgenetic gonads. This rare tumour has been described in three pregnant women. A fourth case in a 26 year old pregnant woman who presented with gonadoblastoma and dysgerminoma, is reported. She had a normal term pregnancy, 46XX chromosomes, normal genitalia, no history of menstrual irregularities and no signs of hyperandrogenism, thereby differing from the other reported cases. The germ cell component of this patient's tumour had undergone rapid overgrowth, most of the tumour comprising pure dysgerminoma. It is suggested that gonadoblastoma may occur in functionally and morphologically normal gonads more often than previous case reports imply.
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Selected References
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- Chellam V. G., Mathew A., Varghese S. Unilateral gonadoblastoma with dysgerminoma in a normal fertile woman--review and report of a case. Indian J Cancer. 1981 Jun;18(2):163–166. [PubMed] [Google Scholar]
- De Bacalao E. B., Dominguez I. Unilateral gonadoblastoma in a pregnant woman. Am J Obstet Gynecol. 1969 Dec 15;105(8):1279–1281. doi: 10.1016/0002-9378(69)90303-2. [DOI] [PubMed] [Google Scholar]
- Elemenoglou J., Korkolopoulou P., Zizi A., Delides G. S. A case of gonadoblastoma in a normal woman with tubal pregnancy. Arch Geschwulstforsch. 1990;60(3):223–226. [PubMed] [Google Scholar]
- Fisher R. A., Salm R., Spencer R. W. Bilateral gonadoblastoma/dysgerminoma in a 46 XY individual: case report with hormonal studies. J Clin Pathol. 1982 Apr;35(4):420–424. doi: 10.1136/jcp.35.4.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lellé R. J., Majewski A. Disgerminom des Ovars in der Schwangerschaft. Geburtshilfe Frauenheilkd. 1985 Nov;45(11):815–816. doi: 10.1055/s-2008-1036655. [DOI] [PubMed] [Google Scholar]
- McDonough P. G., Byrd J. R., Tho P. T., Otken L. Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. Obstet Gynecol. 1976 Mar;47(3):355–358. [PubMed] [Google Scholar]
- Nakashima N., Nagasaka T., Fukata S., Oiwa N., Nara Y., Fukatsu T., Takeuchi J. Ovarian gonadoblastoma with dysgerminoma in a woman with two normal children. Hum Pathol. 1989 Aug;20(8):814–816. doi: 10.1016/0046-8177(89)90080-4. [DOI] [PubMed] [Google Scholar]
- Pratt-Thomas H. R., Cooper J. M. Gonadoblastoma with tubal pregnancy. Am J Clin Pathol. 1976 Jan;65(1):121–125. doi: 10.1093/ajcp/65.1.121. [DOI] [PubMed] [Google Scholar]
- Scully R. E. Gonadoblastoma. A review of 74 cases. Cancer. 1970 Jun;25(6):1340–1356. doi: 10.1002/1097-0142(197006)25:6<1340::aid-cncr2820250612>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
- Steinhardt G. F., Ine M. Y., Subramanian M. G., Hukku B., Perrin E. V., Hoffman W. H. Gonadoblastoma presenting as isosexual precocious puberty in a genetic female. J Pediatr Surg. 1986 Oct;21(10):905–907. doi: 10.1016/s0022-3468(86)80022-7. [DOI] [PubMed] [Google Scholar]