| DNHD1 |
4 |
Involved in microtubule motor activity |
--- |
| PCDH17 |
4 |
Potential calcium-dependent cell-adhesion protein |
Hu X et al. Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers. J Pathol. 2013 Jan;229(1):62-73. |
| USH2A |
4 |
Involved in hearing and vision |
Kim N et al. Somatic mutaome profile in human cancer tissues. Genomics Inform. 2013 Dec;11(4):239-44. doi: 10.5808/GI.2013.11.4.239. Epub 2013 Dec 31. |
| ADCY2 |
3 |
Membrane-bound, calmodulin-insensitive adenylyl cyclase |
Fang LT et al. Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. Int J Oncol. 2014 Jan;44(1):211-21. |
| ATP1B1 |
3 |
ATPase activator activity |
Selvakumar P et al. Epigenetic silencing of Na, K-ATPase β 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma. Epigenetics. 2014 Apr;9(4):579-86. |
| CAD |
3 |
This protein is a “fusion” protein encoding four enzymatic activities of the pyrimidine pathway |
--- |
| ELFN1 |
3 |
Postsynaptic protein that regulates circuit dynamics in the central nervous system |
--- |
| ERP27 |
3 |
Endoplasmic reticulum resident protein 27 |
--- |
| ESR1 |
3 |
Nuclear hormone receptor |
Caiazza F, et al. Estrogen receptors and their implications in colorectal carcinogenesis. Front Oncol. 2015 Feb 2;5:19. |
| F7 |
3 |
Coagulation factor |
Naderi A. Coagulation factor VII is regulated by androgen receptor in breast cancer. Exp Cell Res. 2015 Feb 1;331(1):239-50. |
| ITIH1 |
3 |
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein |
Hamm A et al. Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis. BMC Cancer. 2008 Jan 28;8:25. |
| LHX5 |
3 |
Plays an essential role in the regulation of neuronal differentiation and migration |
--- |
| NFATC1 |
3 |
Plays a role in the inducible expression of cytokine genes in T-cells |
Tripathi MK et al. Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer. Cancer Res. 2014 Dec 1;74(23):6947-57. |
| NOTCH3 |
3 |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination |
Wang XW et al. MicroRNA-206 attenuates tumor proliferation and migration involving the downregulation of NOTCH3 in colorectal cancer. Oncol Rep. 2015 Mar;33(3):1402-10. |
| PTPRS |
3 |
Receptor-type tyrosine-protein phosphatase implicated in cell adhesion |
Wang ZC et al. PTPRS Acts as A Metastatic Suppressor in Hepatocellular Carcinoma by Control of EGFR Induced Epithelial-Mesenchymal Transition. Hepatology. 2015 May 22. |
| Poor prognosis |
| Gene |
# Tumors |
Description |
Reported in literature |
| CSMD1 |
5 |
Membrane receptor |
Farrell C et al. Somatic mutations to CSMD1 in colorectal adenocarcinomas. Cancer Biol Ther. 2008 Apr;7(4):609-13. |
| BRAF |
3 |
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. |
Clancy C et al. BRAF mutation is associated with distinct clinicopathological characteristics in colorectal cancer: a systematic review and meta-analysis. Colorectal Dis. 2013 Dec;15(12):e711-8. |
| CACNA1G |
3 |
Involved in a variety of calcium-dependent processes, including gene expression, cell motility, cell division and cell death |
Berg M et al. Molecular subtypes in stage II-III colon cancer defined by genomic instability:early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A. PLoS One. 2015 Apr 16;10(4):e0122391. |
| CCDC168 |
3 |
Coiled-coil domain-containing protein 168 |
--- |
| DPYD |
3 |
degradation of the chemotherapeutic drug 5-fluorouracil |
Innocenti F. DPYD variants to predict 5-FU toxicity: the ultimate proof. J Natl Cancer Inst. 2014 Nov 7;106(12). |
| DSCAML1 |
3 |
Cell adhesion molecule that plays a role in neuronal self-avoidance. |
--- |
| NRG1 |
3 |
Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters |
Lim B, et al. Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels. Oncotarget. 2015 Jun 1. |
| PAPPA2 |
3 |
Metalloproteinase which specifically cleaves IGFBP-5 |
--- |
| POLE |
3 |
Participates in DNA repair and in chromosomal DNA replication |
Haraldsdottir S, et al. Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations. Gastroenterology. 2014 Dec;147(6):1308-1316. |
| ROBO2 |
3 |
Receptor implicated in cellular migration |
Je EM, et al. Frameshift mutations of axon guidance genes ROBO1 and ROBO2 in gastric and colorectal cancers with microsatellite instability. Pathology. 2013 Dec;45(7):645-50. |
| SLITRK5 |
3 |
Suppresses neurite outgrowth |
--- |
| SPTA1 |
3 |
The major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane |
Iwakawa R, et al. Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing. Carcinogenesis. 2015 Jun;36(6):616-21. |
