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. 2016 Feb 17;7(14):17790–17804. doi: 10.18632/oncotarget.7461

Figure 5. ET-1 secretion by EOC cells requires β-arr1 and HIF-1α.

Figure 5

A. ET-1 protein secretion evaluated by ELISA in conditioned media of HEY cells cultured for 24 h and transfected with SCR or si-β-arr1 or si-HIF1α and/or treated with MAC. Bars are means ±SD of three independent experiments each performed in triplicate; *, p < 0.01 versus CTR. B. Conditioned media of HEY cells stably expressing sh-SCR or sh-β-arr1, and rescued with β-arr1 or β-arr1Q394L expression vectors were evaluated for ET-1 protein secretion by ELISA. Bars are means ±SD from three independent experiments each performed in triplicate; *, p < 0.001 versus SCR; **, p < 0.05 versus sh-β-arr1.