Table 4. Association between the rs1054135 genotype and the risk of TNBC relapse (validation cohort).
SNP | genotype | Disease-free (%) | Relapse (%) | HRa (95% CI) | P value |
---|---|---|---|---|---|
rs1054135 | AA+AG | 88(80.0) | 42 (95.5) | 1.00(Reference) | |
GG | 22 (20.0) | 2(4.5) | 0.14(0.03-0.66) | 0.0026 |
Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between SNPs and recurrence & metastasis risk was adjusted for age, tumour size (≤2cm and >2 cm), lymph-node involvement (no and yes), histological type, menopausal status (no and yes), vascular invasion (no and yes), breast or ovarian cancer history (no and yes), taxane/anthracycline-based chemotherapy (yes or no) and radiotherapy (no and yes).