Abstract
Cytogenetic analysis of short term cultures of fine needle aspirates from two tumours, characterised cytologically as small round cell neoplasms, showed specific clonal chromosomal abnormalities. In both cases the cytogenetic finding of a t(11; 22) (q24; q12) helped determine their diagnosis as peripheral neuroectodermal tumours of the thoraco-pulmonary region (Askin's tumour). These findings suggest that cytogenetics can reliably distinguish neoplasms which present as undifferentiated small round cell tumours.
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Selected References
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- Akhtar M., Ali M. A., Sabbah R., Bakry M., Nash J. E. Fine-needle aspiration biopsy diagnosis of round cell malignant tumors of childhood. A combined light and electron microscopic approach. Cancer. 1985 Apr 15;55(8):1805–1817. doi: 10.1002/1097-0142(19850415)55:8<1805::aid-cncr2820550828>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
- Kristoffersson U., Olsson H., Mark-Vendel E., Mitelman F. Fine needle aspiration biopsy: a useful tool in tumor cytogenetics with special reference to malignant lymphomas. Cancer Genet Cytogenet. 1981 Aug;4(1):53–60. doi: 10.1016/0165-4608(81)90008-x. [DOI] [PubMed] [Google Scholar]
- Miozzo M., Sozzi G., Calderone C., Pilotti S., Lombardi L., Pierotti M. A., Della Porta G. t(11;22) in three cases of peripheral neuroepithelioma. Genes Chromosomes Cancer. 1990 Jul;2(2):163–165. doi: 10.1002/gcc.2870020213. [DOI] [PubMed] [Google Scholar]
- Motzer R. J., Rodriguez E., Reuter V. E., Samaniego F., Dmitrovsky E., Bajorin D. F., Pfister D. G., Parsa N. Z., Chaganti R. S., Bosl G. J. Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. J Natl Cancer Inst. 1991 Mar 6;83(5):341–346. doi: 10.1093/jnci/83.5.341. [DOI] [PubMed] [Google Scholar]
- Schaller R. T., Jr, Schaller J. F., Buschmann C., Kiviat N. The usefulness of percutaneous fine-needle aspiration biopsy in infants and children. J Pediatr Surg. 1983 Aug;18(4):398–405. doi: 10.1016/s0022-3468(83)80189-4. [DOI] [PubMed] [Google Scholar]
- Turc-Carel C., Aurias A., Mugneret F., Lizard S., Sidaner I., Volk C., Thiery J. P., Olschwang S., Philip I., Berger M. P. Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12). Cancer Genet Cytogenet. 1988 Jun;32(2):229–238. doi: 10.1016/0165-4608(88)90285-3. [DOI] [PubMed] [Google Scholar]
- Variend S. Small cell tumours in childhood: a review. J Pathol. 1985 Jan;145(1):1–25. doi: 10.1002/path.1711450102. [DOI] [PubMed] [Google Scholar]
- Whang-Peng J., Triche T. J., Knutsen T., Miser J., Kao-Shan S., Tsai S., Israel M. A. Cytogenetic characterization of selected small round cell tumors of childhood. Cancer Genet Cytogenet. 1986 Apr 1;21(3):185–208. doi: 10.1016/0165-4608(86)90001-4. [DOI] [PubMed] [Google Scholar]