Abstract
A novel morphological feature is described in a patient with myeloma and associated amyloidosis: characteristic clustering (satellitism) of neoplastic plasma cells around macrophages in bone marrow aspirates. Although described in myeloma cell culture, as far as is known, this is the first description of this phenomenon in a patient. This unique association may partly explain the origin of amyloid deposition in tissues and organs.
Full text
PDF

Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Durie B. G., Persky B., Soehnlen B. J., Grogan T. M., Salmon S. E. Amyloid production in human myeloma stem-cell culture, with morphologic evidence of amyloid secretion by associated macrophages. N Engl J Med. 1982 Dec 30;307(27):1689–1692. doi: 10.1056/NEJM198212303072706. [DOI] [PubMed] [Google Scholar]
- Glenner G. G., Page D. L. Amyloid, amyloidosis, and amyloidogenesis. Int Rev Exp Pathol. 1976;15:1–92. [PubMed] [Google Scholar]
- Hopper K. E., Wood P. R., Nelson D. S. Macrophage heterogeneity. Vox Sang. 1979;36(5):257–274. doi: 10.1111/j.1423-0410.1979.tb04434.x. [DOI] [PubMed] [Google Scholar]
- KYLE R. A., BAYRD E. D. "Primary" systemic amyloidosis and myeloma. Discussion of relationship and review of 81 cases. Arch Intern Med. 1961 Mar;107:344–353. doi: 10.1001/archinte.1961.03620030032004. [DOI] [PubMed] [Google Scholar]

