Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1992 Feb;45(2):106–109. doi: 10.1136/jcp.45.2.106

Thyroid peroxidase antibodies in children with autoimmune thyroiditis.

A Väkevä 1, S Kontiainen 1, A Miettinen 1, A Schlenzka 1, J Mäenpää 1
PMCID: PMC495646  PMID: 1541688

Abstract

AIMS: To compare the prevalence of thyroid peroxidase antibodies in 25 children with autoimmune thyroid disorders and in 41 children and young adults with type 1 diabetes, and to test the prevalence of thyrotropin receptor antibodies. METHODS: Two commercially available radioimmunoassays for antibodies to thyroid peroxidase, a commercially available agglutination test of particles coated with thyroid microsomal antigens, and a radioimmunoassay for thyrotropin receptor antibodies were used. Patients and controls were studied. RESULTS: One of the radioimmunoassays detected thyroid peroxidase antibodies not only in all children with autoimmune thyroid disorders and children and young adults with type 1 diabetes and thyroid microsomal antibodies, but also in 20% of healthy control children without microsomal antibodies. With this thyroid peroxidase assay and with microsomal agglutination, 94% of the children with autoimmune thyroiditis, 71% of those with Graves' disease, and over 90% of those with type 1 diabetes and thyroid dysfunction tested positive. In the other radioimmunoassay for thyroid peroxidase antibodies thyroid peroxidase antibody titres in half or more of the children with microsomal antibodies failed to reach the level of positivity given by the producers. Eighty five percent of children with Graves' disease and 71% of those with autoimmune thyroiditis had thyrotropin receptor antibodies but so did 35% of children studied for other endocrinological disorders such as delayed growth or puberty. CONCLUSIONS: Testing patients with well characterised disorders of thyroid function and with other endocrine disorders is important in evaluating the efficacy of new diagnostic tests for thyroid autoantibodies.

Full text

PDF
106

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker B. A., Gharib H., Markowitz H. Correlation of thyroid antibodies and cytologic features in suspected autoimmune thyroid disease. Am J Med. 1983 Jun;74(6):941–944. doi: 10.1016/0002-9343(83)90786-6. [DOI] [PubMed] [Google Scholar]
  2. Banga J. P., Tomlinson R. W., Doble N., Odell E., McGregor A. M. Thyroid microsomal/thyroid peroxidase autoantibodies show discrete patterns of cross-reactivity to myeloperoxidase, lactoperoxidase and horseradish peroxidase. Immunology. 1989 Jun;67(2):197–204. [PMC free article] [PubMed] [Google Scholar]
  3. Bogner U., Kotulla P., Peters H., Schleusener H. Thyroid peroxidase/microsomal antibodies are not identical with thyroid cytotoxic antibodies in autoimmune thyroiditis. Acta Endocrinol (Copenh) 1990 Oct;123(4):431–437. doi: 10.1530/acta.0.1230431. [DOI] [PubMed] [Google Scholar]
  4. Brown R. S., Kertiles L. P., Rosenfield C., Kleinmann R. E., Crigler J. F., Jr Thyrotropin-receptor autoantibodies in children and young adults with Graves' disease. Am J Dis Child. 1986 Mar;140(3):238–241. doi: 10.1001/archpedi.1986.02140170064029. [DOI] [PubMed] [Google Scholar]
  5. Czarnocka B., Ruf J., Ferrand M., Carayon P., Lissitzky S. Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases. FEBS Lett. 1985 Oct 7;190(1):147–152. doi: 10.1016/0014-5793(85)80446-4. [DOI] [PubMed] [Google Scholar]
  6. De Bruin T. W., Braverman L. E., Brown R. S. Heterogeneity of TSH receptor-binding antibodies in Hashimoto's thyroiditis and Graves' disease. Am J Med Sci. 1990 May;299(5):291–297. doi: 10.1097/00000441-199005000-00001. [DOI] [PubMed] [Google Scholar]
  7. Doble N. D., Banga J. P., Pope R., Lalor E., Kilduff P., McGregor A. M. Autoantibodies to the thyroid microsomal/thyroid peroxidase antigen are polyclonal and directed to several distinct antigenic sites. Immunology. 1988 May;64(1):23–29. [PMC free article] [PubMed] [Google Scholar]
  8. Foley T. P., Jr, White C., New A. Juvenile Graves disease: usefulness and limitations of thyrotropin receptor antibody determinations. J Pediatr. 1987 Mar;110(3):378–386. doi: 10.1016/s0022-3476(87)80498-5. [DOI] [PubMed] [Google Scholar]
  9. Hamada N., Jaeduck N., Portmann L., Ito K., DeGroot L. J. Antibodies against denatured and reduced thyroid microsomal antigen in autoimmune thyroid disease. J Clin Endocrinol Metab. 1987 Feb;64(2):230–238. doi: 10.1210/jcem-64-2-230. [DOI] [PubMed] [Google Scholar]
  10. Hashim F. A., Creagh F. M., Hawrani A. E., Parkes A. B., Buckland P. R., Rees Smith B. Characterization of TSH antagonist activity in the serum of patients with thyroid disease. Clin Endocrinol (Oxf) 1986 Sep;25(3):275–281. doi: 10.1111/j.1365-2265.1986.tb01692.x. [DOI] [PubMed] [Google Scholar]
  11. Kohno Y., Naito N., Hiyama Y., Shimojo N., Suzuki N., Tarutani O., Niimi H., Nakajima H., Hosoya T. Thyroglobulin and thyroid peroxidase share common epitopes recognized by autoantibodies in patients with chronic autoimmune thyroiditis. J Clin Endocrinol Metab. 1988 Nov;67(5):899–907. doi: 10.1210/jcem-67-5-899. [DOI] [PubMed] [Google Scholar]
  12. Kontiainen S., Schlenzka A., Koskimies S., Rilva A., Mäenpä J. Autoantibodies and autoimmune diseases in young diabetics. Diabetes Res. 1990 Apr;13(4):151–156. [PubMed] [Google Scholar]
  13. Landin-Olsson M., Karlsson A., Dahlquist G., Blom L., Lernmark A., Sundkvist G. Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children. Diabetologia. 1989 Jun;32(6):387–395. doi: 10.1007/BF00277264. [DOI] [PubMed] [Google Scholar]
  14. Lu C., Kasagi K., Hidaka A., Hatabu H., Iida Y., Konishi J. Simultaneous measurement of TSH-binding inhibitor immunoglobulin and thyroid stimulating autoantibody activities using cultured FRTL-5 cells in patients with untreated Graves' disease. Acta Endocrinol (Copenh) 1990 Sep;123(3):282–290. doi: 10.1530/acta.0.1230282. [DOI] [PubMed] [Google Scholar]
  15. Ludgate M., Mariotti S., Libert F., Dinsart C., Piccolo P., Santini F., Ruf J., Pinchera A., Vassart G. Antibodies to human thyroid peroxidase in autoimmune thyroid disease: studies with a cloned recombinant complementary deoxyribonucleic acid epitope. J Clin Endocrinol Metab. 1989 Jun;68(6):1091–1096. doi: 10.1210/jcem-68-6-1091. [DOI] [PubMed] [Google Scholar]
  16. Mariotti S., Caturegli P., Piccolo P., Barbesino G., Pinchera A. Antithyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab. 1990 Sep;71(3):661–669. doi: 10.1210/jcem-71-3-661. [DOI] [PubMed] [Google Scholar]
  17. Matsuura N., Konishi J., Yuri K., Harada S., Fujieda K., Nohara Y., Mikami Y., Kasagi K., Iida Y., Hosoda A. Comparison of atrophic and goitrous auto-immune thyroiditis in children: clinical, laboratory and TSH-receptor antibody studies. Eur J Pediatr. 1990 May;149(8):529–533. doi: 10.1007/BF01957685. [DOI] [PubMed] [Google Scholar]
  18. Mäenpä J., Lautenschlager I., Nyberg M., Koskimies S., Kontiainen S. Thyroid-infiltrating lymphocytes, thyroid function, and HLA-DR in juvenile autoimmune thyroiditis. Acta Endocrinol (Copenh) 1989 Oct;121(4):573–577. doi: 10.1530/acta.0.1210573. [DOI] [PubMed] [Google Scholar]
  19. Naito N., Saito K., Hosoya T., Tarutani O., Sakata S., Nishikawa T., Niimi H., Nakajima H., Kohno Y. Anti-thyroglobulin autoantibodies in sera from patients with chronic thyroiditis and from healthy subjects: differences in cross-reactivity with thyroid peroxidase. Clin Exp Immunol. 1990 Apr;80(1):4–10. doi: 10.1111/j.1365-2249.1990.tb06433.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Portmann L., Hamada N., Heinrich G., DeGroot L. J. Anti-thyroid peroxidase antibody in patients with autoimmune thyroid disease: possible identity with anti-microsomal antibody. J Clin Endocrinol Metab. 1985 Nov;61(5):1001–1003. doi: 10.1210/jcem-61-5-1001. [DOI] [PubMed] [Google Scholar]
  21. Rootwelt K. Evaluation of a radioreceptor assay for TSH receptor autoantibodies. Scand J Clin Lab Invest. 1988 Apr;48(2):157–164. doi: 10.3109/00365518809085408. [DOI] [PubMed] [Google Scholar]
  22. Schifferdecker E., Schulz F., Schöffling K. Die Bestimmung von TSH-Rezeptor-Antikörpern--Klinische Wertigkeit. Klin Wochenschr. 1986 Jan 2;64(1):8–14. doi: 10.1007/BF01721575. [DOI] [PubMed] [Google Scholar]
  23. Strakosch C. R., Wenzel B. E., Row V. V., Volpé R. Immunology of autoimmune thyroid diseases. N Engl J Med. 1982 Dec 9;307(24):1499–1507. doi: 10.1056/NEJM198212093072407. [DOI] [PubMed] [Google Scholar]
  24. Yokoyama N., Taurog A., Klee G. G. Thyroid peroxidase and thyroid microsomal autoantibodies. J Clin Endocrinol Metab. 1989 Apr;68(4):766–773. doi: 10.1210/jcem-68-4-766. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES