Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1992 Feb;45(2):130–134. doi: 10.1136/jcp.45.2.130

Childhood lymphoma in Yorkshire.

A M Davison 1, P A McKinney 1, C C Bailey 1, I Lewis 1, R A Cartwright 1, C O'Brien 1
PMCID: PMC495651  PMID: 1541692

Abstract

AIMS: A histopathological review of 43 cases of childhood non-Hodgkin's lymphoma (NHL) in an attempt to identify histological variables of prognostic importance. METHOD: Each case was reclassified according to the Working Formulation and an attempt made to allocate an immunophenotype using a panel of monoclonal antibodies. Results were correlated with clinical data on site and survival. RESULTS: Of the 43 cases, 30 were males and 13 females. There were 17 cases of lymphoblastic lymphoma, 15 cases of small non-cleaved cell lymphoma (SNCC), and four cases of large cell lymphoma. The SNCC group was subdivided into 10 cases of Burkitt's lymphoma and five cases of non-Burkitt's lymphoma. An immunophenotype was allocated in 65.1% of cases (23 B, 5 T). The SNCC cases were spread throughout the 0-16 year age range while the lymphoblastic lymphoma cases tended to occur in older children. Most mediastinal tumours were lymphoblastic lymphoma and most abdominal tumours were SNCC. Statistical analysis failed to show a significant difference in survival among histological subgroups or immunophenotypes. CONCLUSION: No histological variables of prognostic importance were identified partly due to the great variation in treatment regimens, standard of supportive care, and prognosis over the period of the study (1972 to 1988).

Full text

PDF
130

Images in this article

132Image
on p.132
132Image
on p.132
133Image
on p.133
133Image
on p.133

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. R., Wilson J. F., Jenkin D. T., Meadows A. T., Kersey J., Chilcote R. R., Coccia P., Exelby P., Kushner J., Siegel S. Childhood non-Hodgkin's lymphoma. The results of a randomized therapeutic trial comparing a 4-drug regimen (COMP) with a 10-drug regimen (LSA2-L2). N Engl J Med. 1983 Mar 10;308(10):559–565. doi: 10.1056/NEJM198303103081003. [DOI] [PubMed] [Google Scholar]
  2. Berard C. W., Jaffe E. S., Braylan R. C., Mann R. B., Nanba K. Immunologic aspects and pathology of the malignant lymphomas. Cancer. 1978 Aug;42(2 Suppl):911–921. doi: 10.1002/1097-0142(197808)42:2+<911::aid-cncr2820420713>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  3. Hall P. A., D'Ardenne A. J., Butler M. G., Habeshaw J. R., Stansfeld A. G. New marker of B lymphocytes, MB2: comparison with other lymphocyte subset markers active in conventionally processed tissue sections. J Clin Pathol. 1987 Feb;40(2):151–156. doi: 10.1136/jcp.40.2.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Holgate C. S., Jackson P., Cowen P. N., Bird C. C. Immunogold-silver staining: new method of immunostaining with enhanced sensitivity. J Histochem Cytochem. 1983 Jul;31(7):938–944. doi: 10.1177/31.7.6189883. [DOI] [PubMed] [Google Scholar]
  5. Holgate C. S., Jackson P., Lauder I., Cowen P. N., Bird C. C. Surface membrane staining of immunoglobulins in paraffin sections of non-Hodgkin's lymphomas using immunogold-silver staining technique. J Clin Pathol. 1983 Jul;36(7):742–746. doi: 10.1136/jcp.36.7.742. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hsu S. M., Raine L. Protein A, avidin, and biotin in immunohistochemistry. J Histochem Cytochem. 1981 Nov;29(11):1349–1353. doi: 10.1177/29.11.6172466. [DOI] [PubMed] [Google Scholar]
  7. Hutchison R. E., Murphy S. B., Fairclough D. L., Shuster J. J., Sullivan M. P., Link M. P., Donaldson S. S., Berard C. W. Diffuse small noncleaved cell lymphoma in children, Burkitt's versus non-Burkitt's types. Results from the Pediatric Oncology Group and St. Jude Children's Research Hospital. Cancer. 1989 Jul 1;64(1):23–28. doi: 10.1002/1097-0142(19890701)64:1<23::aid-cncr2820640105>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  8. Hutchison R. E., Pui C. H., Murphy S. B., Berard C. W. Non-Hodgkin's lymphoma in children younger than 3 years. Cancer. 1988 Oct 1;62(7):1371–1373. doi: 10.1002/1097-0142(19881001)62:7<1371::aid-cncr2820620722>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  9. Jaffe E. S. The role of immunophenotypic markers in the classification of non-Hodgkin's lymphomas. Semin Oncol. 1990 Feb;17(1):11–19. [PubMed] [Google Scholar]
  10. Mann R. B., Jaffe E. S., Braylan R. C., Nanba K., Frank M. M., Ziegler J. L., Berard C. W. Non-endemic Burkitts's lymphoma. A B-cell tumor related to germinal centers. N Engl J Med. 1976 Sep 23;295(13):685–691. doi: 10.1056/NEJM197609232951301. [DOI] [PubMed] [Google Scholar]
  11. Murphy S. B. Childhood non-Hodgkin's lymphoma. N Engl J Med. 1978 Dec 28;299(26):1446–1448. doi: 10.1056/NEJM197812282992606. [DOI] [PubMed] [Google Scholar]
  12. Murphy S. B., Fairclough D. L., Hutchison R. E., Berard C. W. Non-Hodgkin's lymphomas of childhood: an analysis of the histology, staging, and response to treatment of 338 cases at a single institution. J Clin Oncol. 1989 Feb;7(2):186–193. doi: 10.1200/JCO.1989.7.2.186. [DOI] [PubMed] [Google Scholar]
  13. Norton A. J., Isaacson P. G. Lymphoma phenotyping in formalin-fixed and paraffin wax-embedded tissues. I. Range of antibodies and staining patterns. Histopathology. 1989 May;14(5):437–446. doi: 10.1111/j.1365-2559.1989.tb02180.x. [DOI] [PubMed] [Google Scholar]
  14. Norton A. J., Isaacson P. G. Lymphoma phenotyping in formalin-fixed and paraffin wax-embedded tissues: II. Profiles of reactivity in the various tumour types. Histopathology. 1989 Jun;14(6):557–579. doi: 10.1111/j.1365-2559.1989.tb02198.x. [DOI] [PubMed] [Google Scholar]
  15. Norton A. J., Isaacson P. G. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987 Dec;40(12):1405–1412. doi: 10.1136/jcp.40.12.1405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Norton A. J., Ramsay A. D., Smith S. H., Beverley P. C., Isaacson P. G. Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues. J Clin Pathol. 1986 Apr;39(4):399–405. doi: 10.1136/jcp.39.4.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Poppema S., Hollema H., Visser L., Vos H. Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections. Am J Pathol. 1987 Jun;127(3):418–429. [PMC free article] [PubMed] [Google Scholar]
  18. Stiller C. A., Bunch K. J. Trends in survival for childhood cancer in Britain diagnosed 1971-85. Br J Cancer. 1990 Nov;62(5):806–815. doi: 10.1038/bjc.1990.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Vannier J. P. Childhood non-Hodgkin's lymphomas: clinical and therapeutic aspects. Biomed Pharmacother. 1988;42(4):263–269. [PubMed] [Google Scholar]
  20. Wilson J. F., Jenkin R. D., Anderson J. R., Chilcote R. R., Coccia P., Exelby P. R., Kersey J., Kjeldsberg C. R., Kushner J., Meadows A. Studies on the pathology of non-Hodgkin's lymphoma of childhood. I. The role of routine histopathology as a prognostic factor. A report from the Children's Cancer Study Group. Cancer. 1984 Apr 15;53(8):1695–1704. doi: 10.1002/1097-0142(19840415)53:8<1695::aid-cncr2820530813>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  21. Wilson J. F., Kjeldsberg C. R., Sposto R., Jenkin R. D., Chilcote R. R., Coccia P., Exelby R. R., Kersey J., Meadows A., Siegel S. The pathology of non-Hodgkin's lymphoma of childhood: II. Reproducibility and relevance of the histologic classification of "undifferentiated" lymphomas (Burkitt's versus non-Burkitt's). Hum Pathol. 1987 Oct;18(10):1008–1014. doi: 10.1016/s0046-8177(87)80217-4. [DOI] [PubMed] [Google Scholar]
  22. Wollner N., Burchenal J. H., Lieberman P. H., Exelby P., D'Angio G., Murphy M. L. Non-Hodgkin's lymphoma in children. A comparative study of two modalities of therapy. Cancer. 1976 Jan;37(1):123–134. doi: 10.1002/1097-0142(197601)37:1<123::aid-cncr2820370119>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES