Abstract
Twenty four primary stromal tumours of the stomach and small intestine were investigated by silver staining of interphase nucleolar organiser regions (AgNORs) in an attempt to obtain an objective criterion for prediction of malignant tumour behaviour. Malignant tumours tended to have higher AgNOR counts than their benign counterparts, but this increase was small and there was some overlap between the two groups. There was a correlation between the mean AgNOR count and the mitotic count. There was no correlation between tumour size and these two measurements. This study suggests that in these stromal tumours the AgNOR count is not a useful independent predictor of malignant behaviour.
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Selected References
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- Crocker J., Boldy D. A., Egan M. J. How should we count AgNORS? Proposals for a standardized approach. J Pathol. 1989 Jul;158(3):185–188. doi: 10.1002/path.1711580303. [DOI] [PubMed] [Google Scholar]
- Evans H. L. Smooth muscle tumors of the gastrointestinal tract. A study of 56 cases followed for a minimum of 10 years. Cancer. 1985 Nov 1;56(9):2242–2250. doi: 10.1002/1097-0142(19851101)56:9<2242::aid-cncr2820560918>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
- Ploton D., Menager M., Jeannesson P., Himber G., Pigeon F., Adnet J. J. Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level. Histochem J. 1986 Jan;18(1):5–14. doi: 10.1007/BF01676192. [DOI] [PubMed] [Google Scholar]
- Quinn C. M., Wright N. A. The clinical assessment of proliferation and growth in human tumours: evaluation of methods and applications as prognostic variables. J Pathol. 1990 Feb;160(2):93–102. doi: 10.1002/path.1711600202. [DOI] [PubMed] [Google Scholar]
- Ranchod M., Kempson R. L. Smooth muscle tumors of the gastrointestinal tract and retroperitoneum: a pathologic analysis of 100 cases. Cancer. 1977 Jan;39(1):255–262. doi: 10.1002/1097-0142(197701)39:1<255::aid-cncr2820390139>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
- Rowlands D. C., Crocker J., Ayres J. G. Silver staining of nucleolar organizer region associated proteins using polyethylene glycol as the protective colloidal developer. Histochem J. 1990 Oct;22(10):555–559. doi: 10.1007/BF01005978. [DOI] [PubMed] [Google Scholar]
- Sinn H. P., Lehnert T., Kandetzki C., Waldherr R. Nucleolar organizer regions in myogenic stromal tumours of the stomach. Virchows Arch A Pathol Anat Histopathol. 1989;415(4):317–321. doi: 10.1007/BF00718634. [DOI] [PubMed] [Google Scholar]